Welcome to Advanced Search

약물 효과 분석 및 평가

Shanghai Model Organisms Center, Inc.(사)는 약물 효과 평가 서비스는 U-GEMMs 리소스 라이브러리를 기반으로 하여 항염 면역, 항종양, 심혈관계, 호흡계, 대사성 질병 등 약물의 주요 약력학 연구를 수행할 수 있으며, 체내 실험, 메커니즘 검토 및 분자생물학 연구 등 서로 다른 수준의 연구 수요를 충족시켜 신약의 유효성과 안전성을 확립하고 국내외의 제약업체, 생물의학연구소, 신약개발센터, 고등교육기관의 신약 연구개발 기관 등에 전문적인 약력학 평가 서비스를 제공합니다.

Blood Analysis

Mouse serum mouse serum albumin

At Shanghai Model Organisms Center, we use an automatic biochemical analyzer to measure a specific chemical composition of serum according to the principle of photoelectric colorimetry. This can be used to assess liver and kidney functions or measure blood sugar, blood lipids, and electrolytes.

Drug Screening

drug screening high throughput screening for drug discovery

With a comprehensive model organisms service platform that generates the mouse, zebrafish and C. elegans models, Shanghai Model Organisms enables high-throughput drug screening as well as the evaluation and research on drug efficacy, thus accelerating drug development and achieving greater accuracy in the prediction of in vivo interactions.

Gene overexpression

gene overexpression gene overexpression protocol gene overexpression techniques

Generate a mouse model in which an exogenous gene is introduced and overexpressed. An overexpression model can be used to investigate gene functions, promoter functions, or model the pathogenesis of human disease. Depending on the method to introduce foreign DNA, a random transgenes or targeted conditional overexpression model can be created.

Excision and Regeneration of Tissue

liver regeneration subtotal gastrectomy

A mouse tissue regeneration model can be established by an operation of partial tissue excision. Such models can be used to study the changes in morphology, serology and metabolism during tissue regeneration, and hence lay the experimental foundation for studying the mechanisms regulating tissue regeneration.

Metabolic Analysis

Metabolic analysis

There are many mice models used to mimic human metabolic diseases, such as diabetes and obesity, which are caused by nutritional imbalances and metabolic disorders. The detection and analysis of sugar and lipid metabolism phenotypes in these model mice are crucial for the establishment of model mice, the study of disease progression, and the research on the pathogenesis. Shanghai Model Organisms can help your research on metabolism by providing you with a series of testing tools for glucose and lipid metabolisms.

Evaluating the Efficacy of Tumor-targeted Antibody in vivo

immunotherapy immune checkpoint immune checkpoint genes

As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.

Breeding Services

We will delivery the specific genotype model product within specific period by natural breeding or assisted reproduction technology. The specified breeding technologies include natural breeding, assisted reproduction, SPF purification, etc.

Contact Us

As a biotechnology company specializing in animal model R&D, rearing and breeding, as well as analysis and testing, GenoBioTX is dedicated to providing our clients with comprehensive, convenient and professional animal model services.

About Us

Our vision is to become the leader in the field of genetically modified animal models，helping people understand the life science and improving quality of life around the world.