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Models

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Mice

FcγR-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Fcgr2bemFcgr3emFcgr4emFcer1gem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-252414

By knocking out exon1-8 of the Fcgr2b gene, exon1-5 of the Fcgr3 gene, and exon1-5 of the Fcgr4 gene, and introducing mutations into exon 1 of the Fcer1g gene, Fcgr2b, Fcgr3, Fcgr4, and Fcer1g gene knockout mouse models were established.

Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001
Validation Data：Presence  |  Publications：59piece

Prkdc and Il2rg genes were both knocked-out in NOD mice. Lacking mature T, B and NK cells; Low immune rejection against human cells and tissues; Good tumorigenicity so that a small number of cells can form tumors; Significant improvement in the survival of transplanted human cells and tissues; Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models; Suitable as the carrier mice for the transplantation of heterologous cells and tissues.

Mice

NOD SCID

Strain Name：NOD.Cg-Prkdcscid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019
Validation Data：Presence

The strain was developed on background of non-obese diabetic (NOD) mouse with spontaneous scid mutation. NOD SCID mouse, insusceptible to diabetes, possesses reduced activity of T cells and B cells, and defect in innate immunity.NOD SCID mouse is compatible with a wider range of engraftment of cell lines in comparison with nude mouse; And it is broadly applied to construction of PDX models. However, due to a short life span(8-9 months) caused by lethal thymic lymphomas, it is unsuitable for long-term in vivo assays.

Mice

Kremen1-KO

Strain Name：C57BL/6Smoc-Kremen1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190698

Exon 3 of Kremen1 gene was deleted to generate Kremen1 knockout mice.

Rats

Ednrb-KO(SD)

Strain Name：SD-Ednrbem1Smoc Strain State：Developing | Cat. NO.：NR-KO-241785

The exon3-6 of Ednrb gene was knocked out to establish the Ednrb knockout rat model.

Cells

R26-CAG-loxp-tdTomato-loxp2272-Tag-IRES-EGFP-2A-Luc-loxp-loxp2272/Alb-Cre-Tg

Strain Name：R26-CAG-loxp-tdTomato-loxp2272-Tag-IRES-EGFP-2A-Luc-loxp-loxp2272/Alb-Cre-Tg
Strain State ： Construction |  Cat. NO.：NM-YD14

Derived from R26-CAG-loxp-tdTomato-loxp2272-Tag-IRES-EGFP-2A-Luc-loxp-loxp2272/Alb-Cre-Tg mice spontaneous liver cancer model

Cells

Rb1-Flox/Trp53-Flox/R26-CAG-LSL-Luc-2A-EGFP

Strain Name：Rb1-Flox/Trp53-Flox/R26-CAG-LSL-Luc-2A-EGFP
Strain State ： Construction |  Cat. NO.：NM-YD16

Derived from Rb1-Flox/Trp53-Flox/R26-CAG-LSL-Luc-2A-EGFP mice(NM-KI-234513) spontaneous lung cancer model

Cells

R26-CAG-LSL-Kras*G12C-IRES-Luc(BABL/c)

Strain Name：R26-CAG-LSL-Kras*G12C-IRES-Luc(BABL/c)
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-YD15

Derived from R26-CAG-LSL-Kras*G12C-IRES-Luc(BABL/c) mice(NM-KI-200324) spontaneous lung cancer model

Cells

KrasG12D/Mki67-e(2A-tdtomato-2A-AKaluciferase)

Strain Name：KrasG12D/Mki67-e(2A-tdtomato-2A-AKaluciferase)
Strain State ： Validation of target gene expression completed |  Cat. NO.：NM-YD10
Validation Data：Presence

derived from lung cancer model of the offspring produced by mating Mki67-tdTomato-2A-Luc (NM-KI-200223) and Kras-LSL-G12D mice (NM-KI-190003) infected by AAV-Cre virus

Cells

LKB1-KO/Kras-G12D-Luc

Strain Name：LKB1-KO/Kras-G12D-Luc
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-YD07
Validation Data：Presence

derived from LKB1-KO/Kras-G12D-Luc mice spontaneous lung cancer model

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