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An Altered Pattern of Liver Apolipoprotein A-I Isoforms Is Implicated in Male Chronic Hepatitis B Progression

Model Organisms：小鼠 Product & Service：HBV-Tg Research field：Chronic hepatitis B

Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic...

Model Organisms：小鼠 Product & Service：hIL-1βP-Luc Research field：Nervous System

帕金森疾病 神经炎症

How many pairs of mice are generally needed for strain breeding?

birth defect IVF operation male mouse

What measures to take if the mice are having difficulty breeding?

pregnant mice circadian rhythm tocopherol

How do I establish a strain after the transgenic Founder mice are obtained?

C57BL/6J C57BL/6J mice Piggybac transposase

Dysgenesis model

infertility diseases prss37 gene KO mice

Prss37 gene knockout infertility mouse model. SMOC has developed the Prss37 gene knockout mouse model (Prss37 KO, Model No.: NM -KO-00016) by ES cell targeting. It is a homozygous male infertility model.

Psoriasis Mouse Model

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.

Immunology and Inflammation

Inflammatory mouse

Shanghai Model Organisms provides a variety of mouse models of inflammation including exarteritis, chemotherapy-induced intestinal inflammation and inflammatory bowel disease. These models can be applied in researches on the mechanism of inflammation, evaluation of drug efficacy, and others.

Fibrosis

liver fibrosis model

The mouse liver fibrosis model can be generated by surgery or drug induction, which can be used to study the role of genes and proteins in the development of liver fibrosis, to explore the mechanisms underlying liver fibrosis, and to carry out drug efficacy evaluations.