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NOD SCID

Strain Name：NOD.Cg-Prkdc^scid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019
Validation Data：Presence

The strain was developed on background of non-obese diabetic (NOD) mouse with spontaneous scid mutation. NOD SCID mouse, insusceptible to diabetes, possesses reduced activity of T cells and B cells, and defect in innate immunity.NOD SCID mouse is compatible with a wider range of engraftment of cell lines in comparison with nude mouse; And it is broadly applied to construction of PDX models. However, due to a short life span(8-9 months) caused by lethal thymic lymphomas, it is unsuitable for long-term in vivo assays.

Creb1-KO

Strain Name：C57BL/6Smoc-Creb1^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190947

Exon 3-5 of Creb1 gene was deleted to generate Creb1 knockout mice.

Calm1-KO

Strain Name：C57BL/6Smoc-Calm1^em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190703

Exon 2 of Calm1 gene was deleted to generate Calm1 knockout mice.

Rb1-Flox/Trp53-Flox/R26-CAG-LSL-Luc-2A-EGFP

Strain Name：Rb1-Flox/Trp53-Flox/R26-CAG-LSL-Luc-2A-EGFP
Strain State ： Construction |  Cat. NO.：NM-YD16

Derived from Rb1-Flox/Trp53-Flox/R26-CAG-LSL-Luc-2A-EGFP mice(NM-KI-234513) spontaneous lung cancer model

R26-CAG-LSL-Kras*G12C-IRES-Luc(BABL/c)

Strain Name：R26-CAG-LSL-Kras*G12C-IRES-Luc(BABL/c)
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-YD15

Derived from R26-CAG-LSL-Kras*G12C-IRES-Luc(BABL/c) mice(NM-KI-200324) spontaneous lung cancer model

KrasG12D/Mki67-e(2A-tdtomato-2A-AKaluciferase)

Strain Name：KrasG12D/Mki67-e(2A-tdtomato-2A-AKaluciferase)
Strain State ： Validation of target gene expression completed |  Cat. NO.：NM-YD10
Validation Data：Presence

derived from lung cancer model of the offspring produced by mating Mki67-tdTomato-2A-Luc (NM-KI-200223) and Kras-LSL-G12D mice (NM-KI-190003) infected by AAV-Cre virus

LKB1-KO/Kras-G12D-Luc

Strain Name：LKB1-KO/Kras-G12D-Luc
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-YD07
Validation Data：Presence

derived from LKB1-KO/Kras-G12D-Luc mice spontaneous lung cancer model

Trp53-KO/Kras-G12D

Strain Name：Trp53-KO/Kras-G12D
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-YD08
Validation Data：Presence

Trp53-KO/Kras-G12D cell line is murine cell derived from lung cancer model of the offspring produced by mating Trp53-Flox mice (NM-CKO-18005) and Kras-LSL-G12D mice (NM-KI-190003).

Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg

Strain Name：Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-YD13

Derived from Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg mice(NM-XA-234939) spontaneous lung cancer model

Bi-directional differentiation of single bronchioalveolar stem cells during lung repair

Model Organisms：Mouse Product & Service：R26-Confetti2 Research field：lung