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Models

About 103 results
Mice

Bpifa1-KO

Strain Name：C57BL/6Smoc-Bpifa1em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 3 of Bpifa1 gene was deleted to generate Bpifa1 knockout mice.

Mice

Topors-Flox

Strain Name：C57BL/6Smoc-Toporsem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Topors gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Topors gene.

Mice

Topors-KO

Strain Name：C57BL/6Smoc-Toporsem1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 3 of Topors gene was deleted to generate Topors knockout mice.

Mice

Kcne2-KO

Strain Name：C57BL/6Smoc-Kcne2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200278

Exon 2 of Kcne2 gene was deleted to generate Kcne2 knockout mice.

Mice

Acadvl-KO

Strain Name：C57BL/6Smoc-Acadvlem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200908

Exon 3-7 of Acadvl gene was deleted to generate Acadvl knockout mice.

Mice

Acadl-KO

Strain Name：C57BL/6Smoc-Acadlem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-201235

Exon 5 of Acadl gene was deleted to generate Acadl knockout mice.

Mice

Kcnj5-KO

Strain Name：C57BL/6Smoc-Kcnj5em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200288

Exon 3-4 of Kcnj5 gene was deleted to generate Kcnj5 knockout mice.

Mice

C57BL/6

Strain Name：C57BL/6
Strain State：Repository Live | Cat. NO.：SM-001
Validation Data：Presence

It was the first mouse strain to have its genome sequenced. With black coat color, it is recognized as the "standard" inbred strain and provides genetic background for numerous mutant genes. It is characterized by stable strain properties, ease of breeding, uniform stress responses, and high precision in experimental results.

Mice

Cdh5-rtTA-TetO-Cre

Strain Name：B6;129S-Cdh5tm1(rtTA-tetO-Cre)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18006

These mice harbor an M2rtTA-Wpre-polyA-attp-PGK-Neo-polyA-attb-long insulator-tetO-Cre-FRT-Wpre-FRT-polyA-long insulator cassette before ATG of the Cdh5 locus generated homologous recombination.

Mice

KPC

Strain Name：C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096
Validation Data：Presence

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

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