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Models

About 145 results
Mice

Stk4-Flox

Strain Name：C57BL/6Smoc-Stk4em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200226

These mice carry loxP sites flanking exon 4-5 of Stk4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stk4 gene.

Mice

Ctnnb1-Flox

Strain Name：C57BL/6Smoc-Ctnnb1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200154

These mice carry loxP sites flanking exon 2-6 of Ctnnb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ctnnb1 gene.

Mice

Csf2-KO

Strain Name：C57BL/6Smoc-Csf2em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190532

Exon 1-3 of Csf2 gene was deleted to generate Csf2 knockout mice. Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality (Note from MGI).

Mice

Csf2-KO(2)

Strain Name：C57BL/6Smoc-Csf2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-226131

exon 1-2 of Csf2 gene was deleted to generate Csf2 knockout mice. Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality (Note from MGI).

Mice

Nkx2-1-CreERT2

Strain Name：C57BL/6Smoc-Nkx2-1em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200123

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

Mice

Ace2-2A-CreERT2

Strain Name：C57BL/6Smoc-Ace2em2(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200187

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ace2 gene stop codon site. Ace2 encodes angiotensin I converting enzyme 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful for studying lung injury and kidney disease caused by SARS coronavirus infection.

Mice

BALB/c

Strain Name：BALB/cAnSmoc
Strain State：Repository Live | Cat. NO.：SM-003

BALB/c is one of the most widely used inbred lines in biomedical research, especially in immunology and infectious disease research. The incidence of breast tumors is about 10% to 20%. There is a certain number of ovarian, adrenal, pulmonary tumors, and leukemia that occurs. Lung cancer occurs in 26% of female mice and 29% of male mice. The incidence of leukemia is 12% in females and 10% in males. Blood pressure was the highest compared to other inbred mice and had spontaneous hypertension.

Mice

Grp-KO

Strain Name：C57BL/6Smoc-Grpem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190651

Exon 2 of Grp gene was deleted to generate Grp knockout mice.

Mice

Cyp2e1-CreERT2

Strain Name：C57BL/6Smoc-Cyp2e1em1(CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-00047

A kozak-CreERT2-Wpre-polyA cassette was inserted at ATG site of Cyp2e1 gene via CRISPR/Cas mediated recombination.

Mice

Ces1c-Flox

Strain Name：C57BL/6Smoc-Ces1cem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200152

These mice carry loxP sites flanking exon 5 of Ces1c gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ces1c gene.

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