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Models

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Mice

Slc17a7-IRES-Cre

Strain Name：C57BL/6Smoc-Slc17a7em1(IRES2-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200086
Validation Data：Presence

A IRES2-iCre expression cassette was knocked into the Slc17a7 gene stop codon site.

Mice

Nos1-CreERT2

Strain Name：C57BL/6Smoc-Nos1em1(CreERT2-SV40polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200091
Validation Data：Presence

A CreERT2-SV40polyA expression cassette was knocked into the Nos1 gene start codon site.

Mice

Oxt-IRES-Cre

Strain Name：C57BL/6Smoc-Oxtem1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200090
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Oxt gene stop codon site.

Mice

Nos1-IRES-Cre

Strain Name：C57BL/6Smoc-Nos1em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200113
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Nos1 gene stop codon site.

Mice

Aqp5-Cre

Strain Name：C57BL/6Smoc-Aqp5em1(iCre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200062
Validation Data：Presence

A iCre-WPRE-polyA expression cassette was knocked into the Aqp5 gene start codon site.

Mice

Mycn-TRE-EGFP

Strain Name：B6;129S-Mycntm1(TRE-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00008

A TRE site and a loxp EGFP casette were inserted into introns 1-2 to create a Dox-inducible N-myc gene silence mice.

Mice

Tnfsf11-loxP-CC-STOP-loxP-CC-2A-tdTomato-2A-DTR

Strain Name：C57BL/6Smoc-Tnfsf11em1(loxP-CC-STOP-loxP-CC-P2A-tdTomato-T2A-DTR)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-252646

The loxP-CC-STOP-loxP-CC-P2A-tdTomato-T2A-DTR expression cassette was knocked into the Tnfsf11 gene stop codon site.

Mice

Llgl2-rox-loxP-nLacZ-loxP-H2B-EGFP-rox-Avi-V5

Strain Name：C57BL/6Smoc-Llgl2tm1(rox-Linker-loxP-nLacZ-pA-3xpA-loxP-H2B-Kozak-EGFP-pA-pTK-Neo-rox-Kozak-Avi-V5)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-232419

The rox-Linker-loxP-nLacZ-pA-3xpA-loxP-H2B-Kozak-EGFP-pA-pTK-Neo-rox-Kozak-Avi-V5 expression cassette was knocked into the Llgl2 gene start codon site.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：Presence  |  Publications：5piece

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070
Validation Data：Presence

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

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