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Surgical & Preconditioning Services

Gene tracking

marker gene gene tracking

Gene tracers are an important application for genetically engineered mice. Through gene knock-in, exogenous tracer genes were knocked into endogenous genes, enabling labeling and tracing of genes.

Lineage tracing

lineage tracing genetic lineage tracing genetic fate mapping

Genetic lineage tracing is a commonly used and the most effective method for studying the origin and fate of specific cell types. The construction of genetically engineered mouse model is the most important step in the lineage tracing technique.

Liver Cancer PDX Model

PDX PDX models Patient-derived Xenografts

Patient-derived Xenografts (PDX) are advanced preclinical oncology models for drug development. It offers a far better alternative for preclinical drug evaluation as compared to the conventional cell line-derived xenograft model.

Fibrosis

liver fibrosis model

The mouse liver fibrosis model can be generated by surgery or drug induction, which can be used to study the role of genes and proteins in the development of liver fibrosis, to explore the mechanisms underlying liver fibrosis, and to carry out drug efficacy evaluations.

Blood Analysis

Mouse serum mouse serum albumin

At Shanghai Model Organisms Center, we use an automatic biochemical analyzer to measure a specific chemical composition of serum according to the principle of photoelectric colorimetry. This can be used to assess liver and kidney functions or measure blood sugar, blood lipids, and electrolytes.

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.

Imaging Analysis

Animal imaging micro CT

shanghai Model Organisms provides services for microCT and IVIS whole-body in vivo imaging/fluorescence quantitative analysis of small animals.

Rb1 CKO Mouse Model

With the ability to avoid the risk of death caused by homozygous and systemic knockout, our own-developed Rb1 conditional knockout mice (Rb1-CKO) can be used to study cancer, cell cycle or aging.

Humanized Mice

NMG mice with human-derived CD34+ hematopoietic stem cells can be used for reconstruction of multi-lineage human immune cells, and represent effective model animals for studies on immuno-oncology and infectious diseases.