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Models

About 199 results
Mice

hFCGR1A

Strain Name：C57BL/6Smoc-Fcgr1tm3(hFCGR1A)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000072

The endogenous mouse Fcgr1 gene was replaced by human FCGR1A gene.

Mice

hIL6

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18017

This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting.

Mice

Fcgrt-KO

Strain Name：C57BL/6Smoc-Fcgrtem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-00133

Fcgrt-KO mice (Stock No.NM-KO-00133）carry a knockout allele derived from the targeted deletion of exon 1-4.

Mice

Taz-Flox

Strain Name：C57BL/6Smoc-Tazem2(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200001

These mice carry loxP sites flanking exon5-10 of Taz gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Taz gene.

Mice

hCD19/hCD3E

Strain Name：C57BL/6Smoc-Cd19em1(hCD19)Cd3eem1(hCD3E)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190027

This CD19 and CD3E double knockin strain is established by crossing CD19-HU and CD3E-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hTLR9/hOX40

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Tnfrsf4em3(hTNFRSF4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024

This TLR9 and OX40 double knockin strain is established by crossing TLR9-HU and OX40-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6raem1(hIL6R)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4em1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

h4-1BB(2)/hCD3E(2)

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Cd3eem2(hCD3E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210409

h4-1BB(2)(NM-HU-190077) was crossed with hCD3E(2)(NM-HU-210023)to generate h4-1BB(2)/hCD3E(2) mice.

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