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Models

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Mice

hPD-L1/hSIRPA(2)

Strain Name:C57BL/6Smoc-Sirpatm2(hSIRPA)Cd274tm1(hCD274)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000099

hPD-L1(NM-HU-00062) was crossed with hSIRPA(2)(NM-HU-18015) to generate hPD-L1/hSIRPA(2).

Mice

hNKG2A/hCD94

Strain Name:C57BL/6Smoc-Nkg2tm1(hNKG2A)Cd94tm1(hCD94)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000016

The endogenous mouse Nkg2 and Cd94 gene was replaced by human NKG2A and CD94 gene.

Mice

hPD-1/hCD27(2)

Strain Name:C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd27tm2(hCD27)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000096

hPD-1(NM-HU-00015) was crossed with hCD27(2)(NM-HU-190035) to generate hPD-1/hCD27(2).

Mice

hICOS(BALB/c)

Strain Name:BALB/cAnSmoc-Icostm1(hICOS)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-2000046

The endogenous mouse Icos gene was replaced by human ICOS gene.

Mice

hIL3(NMG)

Strain Name:NOD.Cg-PrkdcscidIl2rgem1Il3tm4(hIL3)/Smoc
Strain State:Repository Live | Cat. NO.:NM-NSG-007

The hIL7(NM-HU-190009) mice were backcrossed to NMG genetic background, to create the new strain of hIL7(NMG) (NNMG-007) mice.

Mice

hFCGR1A

Strain Name:C57BL/6Smoc-Fcgr1tm3(hFCGR1A)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000072
Validation Data:Presence

The endogenous mouse Fcgr1 gene was replaced by human FCGR1A gene.

Mice

hCD4(BALB/c)

Strain Name:BALB/cAnSmoc-Cd4tm3(hCD4)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000053
Validation Data:Presence

The endogenous mouse Cd4 gene was replaced by human CD4 gene.

Mice

hCXCR1

Strain Name:C57BL/6Smoc-Cxcr1tm1(hCXCR1)Smoc
Strain State:Developing | Cat. NO.:NM-HU-2000024

The endogenous mouse Cxcr1 gene was replaced by human CXCR1 gene.

Mice

hIL6

Strain Name:C57BL/6Smoc-Il6tm1(hIL6)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-18017

This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting.

Mice

hTLR7/hTLR8

Strain Name:C57BL/6Smoc-Tlr7tm3(hTLR7)Tlr8tm3(hTLR8)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000015

The endogenous mouse Tlr7 and Tlr8 gene was replaced by human TLR7 and TLR8 gene.

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