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Models

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Mice

Adcyap1r1-KO

Strain Name：C57BL/6Smoc-Adcyap1R1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190669

Exon 4-7 of Adcyap1r1 gene was deleted to generate Adcyap1r1 knockout mice.

Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001
Validation Data：Presence  |  Publications：59piece

Prkdc and Il2rg genes were both knocked-out in NOD mice. Lacking mature T, B and NK cells; Low immune rejection against human cells and tissues; Good tumorigenicity so that a small number of cells can form tumors; Significant improvement in the survival of transplanted human cells and tissues; Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models; Suitable as the carrier mice for the transplantation of heterologous cells and tissues.

Mice

hCD19/hCD3E

Strain Name：C57BL/6Smoc-Cd19tm1(hCD19)Cd3etm1(hCD3E)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190027
Validation Data：Presence

This CD19 and CD3E double knockin strain is established by crossing CD19-HU and CD3E-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hTLR9/hOX40

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Tnfrsf4tm3(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024

This TLR9 and OX40 double knockin strain is established by crossing TLR9-HU and OX40-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6ratm1(hIL6R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025
Validation Data：Presence

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4tm1(hCTLA4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Sigmar1-KO

Strain Name：C57BL/6Smoc-Sigmar1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190644

Exon 2-4 of Sigmar1 gene was deleted to generate Sigmar1 knockout mice.

Mice

Btk-KO

Strain Name：C57BL/6Smoc-Btkem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190005

This Btk knockout mouse model was generated by deleting the Exon 4-5 region of the Btk .

Mice

C1qa-Flox

Strain Name：C57BL/6Smoc-C1qaem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200084

These mice carry loxP sites flanking exon 3 of C1qa gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of C1qa gene.

Mice

Il17ra-Flox

Strain Name：C57BL/6Smoc-Il17raem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200103

These mice carry loxP sites flanking exon 2-3 of Il17ra gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Il17ra gene.

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