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B2m-KO(NMG,2)

Strain Name：NOD-Prkdc^scidIl2rg^em1B2m^emSmoc
Strain State：Developing | Cat. NO.：NM-KO-220540

The B2m-KO(NOD-scid)(NM-KO-18035) mice were backcrossed to NMG genetic background, to create the new strain of B2m-KO(NMG,2)(NM-KO-220540) mice.

Ahr-KO

Strain Name：C57BL/6Smoc-Ahr^em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18008

Exon3 of Ahr gene was deleted to generate Ahr knockout mice. The homozygous female mice of this strain had impaired fertility. There have been reports of deaths caused by genetic modification. For details, click on the MGI ID in the genetic information.

MHC ClassII(I-A/I-E)-KO(NMG)

Strain Name：NOD-Prkdc^scidIl2rg^em1H2-Ab1^em1H2-Aa^em1H2-Eb1^em1H2-Eb2^em1H2-Ea-ps ^em1Smoc
Strain State：Developing | Cat. NO.：NM-NSG-003

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.  These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

MHC Class II(I-A/I-E)-KO(Nod-Scid)

Strain Name：NOD-Prkdc^scidH2-Ab1^em1H2-Aa^em1H2-Eb1^em1H2-Eb2^em1H2-Ea-ps^em1Smoc
Strain State：Developing | Cat. NO.：NM-KO-18057

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.

MHCII/B2m-KO(NMG)

Strain Name：NOD.Cg-Prkdc^scidIl2rg^em1H2-Ab1^em1H2-Aa^em1H2-Eb1^em1H2-Eb2^em1H2-Ea-ps ^em1B2m ^em1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-014

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Il9r-KO

Strain Name：C57BL/6Smoc-Il9r^em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190511

Exon 3-7 of Il9r gene was deleted to generate Il9r knockout mice.

HCC1937

Strain Name：HCC1937
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-R08

The HCC1937 cell line is derived initially from the mammary gland of a 23-year-old Caucasian female with breast carcinoma that is associated with genetic predisposition.

SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.

These Mice Are About to Go Viral Because of the Nobel Prize!

microRNA (miRNA) microRNA mouse models Nobel Prize microRNA discovery genetically engineered mice miRNA in gene regulation miRNA therapeutics miRNA in cancer research customized mouse models contract research organization (CRO) preclinical drug discovery

The 2024 Nobel Prize in Physiology or Medicine awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) highlights its revolutionary role in gene regulation and disease treatment. This article explores miRNA's impact on neuroscience, cancer, and cardiovascular research. GenoBioTX offers advanced microRNA mouse models and customized genetic solutions, empowering researchers with essential tools to drive innovation in miRNA studies and therapeutic developments.

Harnessing the Power of the Cre-loxP System: Benefits, Challenges, and Applications

This webinar will introduce the Cre-loxP system, a powerful genetic tool that has revolutionized biological research by allowing for conditional gene knockout, knockdown, and overexpression. We will cover the history of the genetic recombination systems, discuss how they enable precise control of gene expression in specific cell types or at specific developmental stages, and present GenoBioTX’s genetically modified models utilizing this method.