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GEMM-Derived Allografts

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.

Cancer Model

research on cancer cancer model mouse models of cancer

The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.

Gene Knock-in

gene knock in knock in mice knock in mouse

Knock-in represents the introduction of specific mutations or exogenous genes, such as point mutations (mimicking human genetic disease) at the selected location or reporter genes (e.g., EGFP, RFP, mCherry, YFP, LacZ, Luciferase etc.) or functional cDNAs (such as Cre, Dre etc.) into a specific genomic locus through homologous recombination, thereby allowing the exogenous DNA fragment to be expressed. A simultaneous occurrence of knock-in and knock-out can be achieved by replacing a murine endogenous gene with a foreign DNA fragment.

Who We are

Disease Mouse Models (Non-genetically-engineered)

diseases mice diseases model non genetically modified organisms

Shanghai Model Organisms has established a library of typical mouse models of human diseases through surgery or drug induction, thereby providing useful animal models for the research on pathogenesis of related diseases, functional studies of genes or proteins in diseases, screening of disease drugs and evaluation of therapeutic effects, etc.

Research on Diseases

genetics diseases studies diseases research diseases

Shanghai Model Organisms provides a professional R&D platform for genetically-engineered mouse, zebrafish and nematode models, a service platform for phenotyping, and a rich repository of disease mouse models to support your studies on disease genetics, pathogenesis, drug treatments, and more.

Customize your genetically engineered models

knockout mouse transgenic mouse transgenic mouse models

The scientific team at Shanghai Model Organisms Center, Inc, comprising of seasoned molecular biologists and technicians, is dedicated to providing highly customizable, genetically engineered models to global researchers.

About Us

Our vision is to become the leader in the field of genetically modified animal models，helping people understand the life science and improving quality of life around the world.

Database

mouse genome database

Here you can find links to databases for mouse genomes and other resources.