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Disease Mouse Models (Non-genetically-engineered)

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Shanghai Model Organisms has established a library of typical mouse models of human diseases through surgery or drug induction, thereby providing useful animal models for the research on pathogenesis of related diseases, functional studies of genes or proteins in diseases, screening of disease drugs and evaluation of therapeutic effects, etc.

Overview of gene editing technology

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Services

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Shanghai Model Organisms offers a full range of model organism services, including model customization services, research-ready models, breeding, phenotyping and drug screening. Mouse, rat, zebrafish and C. elegans models are available to meet different research needs.

Cancer Model

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The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.

Applications of Animal Models

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The model animal has played an important role in the history of life sciences and medicine, with a wide range of application in biology, medicine, molecular biology, molecular genetics, immunology and other fields.

Why We Need Humanized Mice?

Mouse

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Mice have long been the prime choice for model organisms. In more than 100 years, mice have been widely used by researchers in the fields of physiology, pathology, pharmacology, toxicology, and behavioral science. With the establishment of gene targeting technology, many researchers have made their way to the Nobel Prize.

Lineage tracing

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Genetic lineage tracing is a commonly used and the most effective method for studying the origin and fate of specific cell types. The construction of genetically engineered mouse model is the most important step in the lineage tracing technique.

Gene Knockout

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Expedite your research with highly customizable, gene knockout mouse models that provide thorough insight into key genetic mechanisms.

Gene Knock-in

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Knock-in represents the introduction of specific mutations or exogenous genes, such as point mutations (mimicking human genetic disease) at the selected location or reporter genes (e.g., EGFP, RFP, mCherry, YFP, LacZ, Luciferase etc.) or functional cDNAs (such as Cre, Dre etc.) into a specific genomic locus through homologous recombination, thereby allowing the exogenous DNA fragment to be expressed. A simultaneous occurrence of knock-in and knock-out can be achieved by replacing a murine endogenous gene with a foreign DNA fragment.