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Models

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Mice

Ahr-KO

Strain Name：C57BL/6Smoc-Ahrem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18008

Exon3 of Ahr gene was deleted to generate Ahr knockout mice. The homozygous female mice of this strain had impaired fertility. There have been reports of deaths caused by genetic modification. For details, click on the MGI ID in the genetic information.

Mice

Stat3-KO(in-frame mutation)

Strain Name：C57BL/6Smoc-Stat3emSmoc
Strain State：Repository Live | Cat. NO.：NM-KO-210186

exon 18-20 of Stat3 gene was deleted to generate Stat3 knockout mice. The targeted knockout region mirrors that of the NM-CKO-200225 strain, with the experimental strategy designed according to published methodologies (PMID: 14566054; 17660847; 12571365).Lethality associated with this genetic modification has been documented. For details, click on the MGI ID in the genetic information.

Mice

MHC ClassII(I-A/I-E)-KO(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1Smoc
Strain State：Developing | Cat. NO.：NM-NSG-003

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.  These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

MHC Class II (I-A/I-E) -KO

Strain Name：C57BL/6Smoc-H2-Ab1em1H2-Aaem1 H2-Eb1em1H2-Eb2em1H2-Ea-ps em1 Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18032

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

MHC Class II(I-A/I-E)-KO(Nod-Scid)

Strain Name：NOD-PrkdcscidH2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-psem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-18057

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

MHCII/B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1B2m em1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-014

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Mice

C57BL/6

Strain Name：C57BL/6Smoc
Strain State：Repository Live | Cat. NO.：SM-001

C57BL/6 mice have a high reproductive capacity, a long life span, and a low tumor susceptibility. Male mice are aggressive and fight frequently. Diet can cause obesity, type II diabetes, and atherosclerosis in these mice. The C57BL/6 mouse is the first to have its entire genome sequenced. It is the most extensively used inbred mouse strain as a genetic basis for congenic and mutant mice. It is also used in genetics, metabolism, immunology, neurology, behavioral research, pharmacodynamics, and medication safety evaluation.

Mice

Il9r-KO

Strain Name：C57BL/6Smoc-Il9rem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190511

Exon 3-7 of Il9r gene was deleted to generate Il9r knockout mice.

Mice

Slc6a1-S295L

Strain Name：C57BL/6Smoc-Slc6a1em2(S295L)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190014

These mice carry a p.S295L mutation in Slc6a1 gene .

Mice

R26-CAG-LSL-GqDREADD(hM3Dq)-2A-mCitrine

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-HA-GqDREADD(hM3Dq)-P2A-mCitrine-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190106

These mice harbor a CAG-LSL-HA-GiDREADD（hM3Dq)-P2A-mCitrine-WPRE-polyA cassette in the Rosa26 locus generated by homologous recombination.

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