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Mice

Pcsk1-Flox

Strain Name：C57BL/6Smoc-Pcsk1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2100824

These mice carry loxP sites flanking exon 2-5 of Pcsk1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pcsk1 gene.

Mice

Gli1-CreERT2

Strain Name：C57BL/6Smoc-Gli1em1(CreERT2-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200073

A CreERT2-Wpre-polyA expression cassette was knocked into the Gli1 gene start codon site. Gli1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. When these Gli1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.

Mice

Nedd4-Flox

Strain Name：C57BL/6Smoc-Nedd4em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-2100778

These mice carry loxP sites flanking exon 7-10 of Nedd4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nedd4 gene.

Mice

Cadm3-Flox

Strain Name：C57BL/6Smoc-Cadm3tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2119174

These mice carry loxP sites flanking exon 2-6 of Cadm3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cadm3 gene.

Mice

Nkx3-1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Nkx3-1em1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200071

A IRES-CreERT2 expression cassette was knocked into the Nkx3-1 gene stop codon site.

Mice

Nek5-Flox

Strain Name：C57BL/6Smoc-Nek5em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2116908

These mice carry loxP sites flanking target exon 3 of Nek5 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nek5 gene.

Mice

Prox1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Prox1em1(IRES-CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200119

A IRES-CreERT2-pA expression cassette was knocked into the Prox1 gene stop codon site. Prox1 encodes a transcription factor (prospero-related homeobox 1) that is necessary for the formation and maintenance of lymphatic vessels. When Prox1-IRES-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in PROX1positive cells.

Mice

Nedd8-Flox

Strain Name：C57BL/6Smoc-Nedd8em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-233829

These strains carry loxP sites flanking exon 2-3 of Nedd8 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nedd8 gene.

Mice

Upk3b-KO

Strain Name：B6;129S-Upk3btm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00023

An Frt-Neo-Frt cassette replaced exons 1-2 of Upk13 gene.

Mice

Cdkn1a-Flox

Strain Name：C57BL/6Smoc-Cdkn1aem2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200033

These mice carry loxP sites flanking exon 2-3 of Cdkn1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cdkn1a gene.

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