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Models

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Mice

H11-CAG-EGFP

Strain Name：C57BL/6Smoc-Igs2 em1(CAG-EGFP-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00066

These mice harbor a CAG promoter-driven EGFP report gene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination.

Mice

R26-CreERT2

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200041
Validation Data：Presence

These mice harbor a SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA cassette in the Rosa26 locus generated by homologous recombination. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in multiple tissues after tamoxifen treatment.

Mice

R26-CAG-2xKRAB-dCas9-IRES-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-Loxp-2xKRAB-dCas9-IRES-EGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18007
Validation Data：Presence

These mice harbor a CAG-LSL-2xKRAB-dCas9-IRES-EGFP-WPRE-pA conditional expression cassette in mouse Rosa26 loci via homologous recombination. This strain can be used in CRISPR mediated target gene transcriptional inhibition (CRISPRi). The loxp-stop-loxp cassette was deleted.

Mice

R26-CAG-LNL-Fen1-IRES-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LNL-Fen1-3XHA-IRES-EGFP-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00126

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Fen1 gene followed by 3xHA-IRES-EGFP tag coexpression cassette. The targeted mutation was inserted into the Rosa26 locus by homologous recombination.

Mice

Pten-Flox

Strain Name：C57BL/6Smoc-Ptenem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18004
Publications：1piece

These Pten flox mice possess loxP sites flanking exons 5 via CRISPR/Cas mediated recombination. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Tet3-Flox(2)

Strain Name：C57BL/6Smoc-Tet3em2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-18003

These Tet3 flox mice possess loxP sites flanking exons 4 via CRISPR/Cas mediated recombination. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Alb-CreERT2

Strain Name：B6.129S-Albtm1.1(CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00002
Validation Data：Presence  |  Publications：1piece

Exons 1-7 were replaced by CreERT2 and a loxp neo casette. The KI mice have a tamoxifen-inducible cre-mediated recombination system.This strain has removed the Neo screening gene.

Mice

H11-CAG-LSL-hACHE

Strain Name：C57BL/6Smoc-Igs2tm1(CAG-LSL-ACHE-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00067

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven ACHE gene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. ACHE is expressed when bred to mice that express Cre recombinase.

Mice

R26-CAG-LNL-CaMPARI

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LNL-CaMPARI)-NSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00090

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven CaMPARI gene. The targeted mutation was inserted into the Gt(ROSA)26Sor locus by homologous recombination.

Mice

R26-Renilla-Luc

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-Renilla-Luc)-NSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00091

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Renilla-Luc gene. The targeted mutation was inserted into the Gt(ROSA)26Sor locus by homologous recombination.

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