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Models

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Mice

hAPOE2

Strain Name：C57BL/6Smoc-Apoetm4(hAPOE2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190013

This APOE2 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE2 corresponding sequence by homologous recombination.

Mice

hIl5

Strain Name：C57BL/6Smoc-Il5tm3(hIL5)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190001

This IL5 humanized mouse model was established by replacing the mouse Il5 gene coding exons and introns with the human TLR9 corresponding sequence by homologous recombination.

Mice

hAPOE4

Strain Name：C57BL/6Smoc-Apoetm2(hAPOE4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190002

This APOE4 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE4 corresponding sequence by homologous recombination.

Mice

hAPOE3

Strain Name：C57BL/6Smoc-Apoetm3(hAPOE3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190003

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.

Mice

hHLA-E

Strain Name：C57BL/6Smoc-Igs2em1(hHLA-E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200221

The endogenous human HLA-E gene (about 11kb) was knocked into the H11 locus via CRISPR/Cas9 mediated recombination.

Mice

hIL6

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18017

This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting.

Mice

H11-CAG-EGFP

Strain Name：C57BL/6Smoc-Igs2 em1(CAG-EGFP-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00066

These mice harbor a CAG promoter-driven EGFP report gene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination.

Mice

R26-CAG-LNL-Cas9-IRES-Luc

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LNL-Cas9-IRES-Luciferase-pA)
Strain State：Repository Live | Cat. NO.：NM-KI-18002

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Cas9 gene followed by IRES-Luciferase coexpression cassette. The targeted mutation was inserted into the Rosa26 locus by homologous recombination.

Mice

R26-CAG-2xKRAB-dCas9-IRES-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-Loxp-2xKRAB-dCas9-IRES-EGFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18007

These mice harbor a CAG-LSL-2xKRAB-dCas9-IRES-EGFP-WPRE-pA conditional expression cassette in mouse Rosa26 loci via homologous recombination. This strain can be used in CRISPR mediated target gene transcriptional inhibition (CRISPRi). The loxp-stop-loxp cassette was deleted.

Mice

R26-CreERT2

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200041

These mice harbor a SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA cassette in the Rosa26 locus generated by homologous recombination. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in multiple tissues after tamoxifen treatment.

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