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Models

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Mice

Zbtb46-IRES-Cre

Strain Name：C57BL/6Smoc-Zbtb46em1(IRES-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200096
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Zbtb46 gene stop codon site.

Mice

Shh-CreERT2

Strain Name：C57BL/6Smoc-Shhem1(CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200145
Validation Data：Presence

A CreERT2-WPRE-polyA expression cassette was knocked into the Shh gene start codon site.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039
Validation Data：Presence  |  Publications：2piece

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

hANGPTL3(4)

Strain Name：C57BL/6Smoc-Angptl3tm1(hANGPTL3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210036
Validation Data：Presence

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(3)(Stock No.NM-HU-210037) mice function similarly to hANGPTL3(2) mice, for more detailed information please contact our technical advisor.

Mice

hGLP1R

Strain Name：C57BL/6Smoc-Glp1rtm2(hGLP1R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200220
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Glp1r gene was completely or partially replaced by human hGLP1R gene via CRISPR/Cas9 mediated recombination.

Mice

hEPCAM

Strain Name：C57BL/6Smoc-Epcamtm1(hEPCAM)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210032
Validation Data：Presence

The endogenous mice Epcam gene was completely or partially replaced by human EPCAM gene via ESC targeting.

Mice

hANGPTL3(3)

Strain Name：C57BL/6Smoc-Angptl3tm2(hANGPTL3)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-210037
Validation Data：Presence

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(4)(Stock No.NM-HU-210036) mice function similarly to hANGPTL3(3) mice, for more detailed information please contact our technical advisor.

Mice

hCRLF2

Strain Name：C57BL/6Smoc-Crlf2tm1(hCRLF2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210028
Validation Data：Presence

The endogenous mice Crlf2 gene was completely or partially replaced by human CRLF2 gene via ESC targeting.

Mice

hCD3E(2)

Strain Name：C57BL/6Smoc-Cd3etm2(hCD3E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210023

The endogenous mice Cd3e gene was replaced by human CD3E gene. While hCD3E(Stock No.NM-HU-00114) mice function similarly to hCD3E(2) mice,for more detailed information please contact our technical advisor.

Mice

hSIGLEC8(2)

Strain Name：C57BL/6Smoc-Siglecftm1(hSIGLEC8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210033
Validation Data：Presence

The endogenous mice Siglecf gene was replaced by human SIGLEC8 gene. While hSIGLEC8(Stock No.NM-HU-204983) mice function similarly to hSIGLEC8(2) mice,for more detailed information please contact our technical advisor.

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