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Mice

Slco1c1-2A-CreERT2

Strain Name：C57BL/6Smoc-Slco1c1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200262
Validation Data：Presence

2A-CreERT2 expression cassette was knocked into the Slco1c1 gene stop codon site. Slco1c1 encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. When Slco1c1-2A-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLCO1C1 positive cells.

Mice

Lyz2-IRES-DTRGFP

Strain Name：C57BL/6Smoc-Lyz2em3(IRES-DTREGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190041
Validation Data：Presence

A IRES-DTREGFP expression cassette was knocked into the Lyz2 gene stop codon site.

Mice

Tagln-2A-DreERT2

Strain Name：C57BL/6Smoc-Taglnem1(2A-DreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215038
Validation Data：Presence

2A-DreERT2 expression cassette was knocked into the Tagln gene. Tagln-2A-DreERT2(2) (Stock No.NM-KI-215094) is similar to this strain.

Mice

Gp1ba-2A-Cre

Strain Name：C57BL/6Smoc-Gp1baem1(T2A-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200172
Validation Data：Presence

A T2A-iCre expression cassette was knocked into the Gp1ba gene stop codon site.

Mice

Pdx1-2A-Cre

Strain Name：C57BL/6Smoc-Pdx1em(2A-Cre)1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-225082
Validation Data：Presence

2A-Cre expression cassette was knocked into the Pdx1 gene .

Mice

Tg-2A-CreERT2

Strain Name：C57BL/6Smoc-Tgem1(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215040
Validation Data：Presence

2A-CreERT2-WPRE-polyA expression cassette was knocked into the Tg gene.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：Presence  |  Publications：5piece

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Il1b-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1bem1(Luc-eGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00010
Validation Data：Presence  |  Publications：2piece

A Luciferase-2A-EGFP-pA cassette was inserted at ATG site of mouse Il1b gene. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1b.

Mice

Trdc-IRES-CreERT2

Strain Name：C57BL/6Smoc-Trdcem1(IRES-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-231464
Validation Data：Presence

The IRES-CreERT2 expression cassette was inserted after the termination codon of the mouse Trdc gene.

Mice

R26-CAG-LSL-Cas9-IRES-Luc

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Cas9-IRES-Luciferase-pA)
Strain State：Repository Live | Cat. NO.：NM-KI-18002

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Cas9 gene followed by IRES-Luciferase coexpression cassette. The targeted mutation was inserted into the Rosa26 locus by homologous recombination.

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