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Mice

Pdx1-2A-Cre

Strain Name：C57BL/6Smoc-Pdx1em(2A-Cre)1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-225082

2A-Cre expression cassette was knocked into the Pdx1 gene .

Mice

Il1b-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1bem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00010

A Luciferase-2A-EGFP-pA cassette was inserted at ATG site of mouse Il1b gene. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1b.

Mice

hIL17A/hIL17F

Strain Name：C57BL/6Smoc-Il17atm1(hIL17A)Il17fem2(hIL17F)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200281

The endogenous mouse Il17a&Il17f genes were replaced by human IL17A&IL17F gene.

Mice

Trdc-IRES-CreERT2

Strain Name：C57BL/6Smoc-Trdcem1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-231464

The IRES-CreERT2 expression cassette was inserted after the termination codon of the mouse Trdc gene.

Mice

Zbtb46-IRES-Cre

Strain Name：C57BL/6Smoc-Zbtb46em1(IRES-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200096

A  IRES-iCre expression cassette was knocked into the Zbtb46 gene stop codon site. This strain carries a significant risk of reproductive system leakage. Avoid using homozygotes and female Cre mice. It is recommended to use male mice, as they have a lower probability of leakage. After mating, offspring should be genotyped and promptly checked for any occurrence of reproductive leakage.

Mice

Shh-CreERT2

Strain Name：C57BL/6Smoc-Shhem1(CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200145

A  CreERT2-WPRE-polyA expression cassette was knocked into the Shh gene start codon site. Expression of Shh-CreERT2 may be "leaky" at 1-month-old mice without tamoxifen.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

hANGPTL3(4)

Strain Name：C57BL/6Smoc-Angptl3em1(hANGPTL3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210036

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(3)(Stock No.NM-HU-210037) mice function similarly to hANGPTL3(2) mice, for more detailed information please contact our technical advisor.

Mice

hGLP1R

Strain Name：C57BL/6Smoc-Glp1rem2(hGLP1R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200220

The endogenous mouse Glp1r gene was completely or partially replaced by human hGLP1R gene via CRISPR/Cas9 mediated recombination.

Mice

hEPCAM

Strain Name：C57BL/6Smoc-EpCAMtm1(hEpCAM)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210032

The endogenous mice Epcam gene was completely or partially replaced by human EPCAM gene via ESC targeting.

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