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Models

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Mice

hSIGLEC8

Strain Name：C57BL/6Smoc-Siglecetm1(hSIGLEC8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204983

The endogenous mice Siglece gene was replaced by human SIGLEC8 gene. While hSIGLEC8(2)(Stock No.NM-HU-210033) mice function similarly to hSIGLEC8 mice,for more detailed information please contact our technical advisor.

Mice

hICOS

Strain Name：C57BL/6Smoc-Icostm1(hICOS)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00052
Validation Data：Presence

The endogenous mouse Icos gene was replaced by human ICOS gene. While hICOS(2)(Stock No.NM-HU-190030) mice function similarly to hICOS mice,for more detailed information please contact our technical advisor.

Mice

Opn4-Cre

Strain Name：C57BL/6Smoc-Opn4em1(Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200304
Validation Data：Presence

Cre-WPRE-polyA expression cassette was knocked into the Opn4 gene start codon site. The melanopsin gene (Opn4) encodes a functional photopigment. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying circadian rhythm regulation.

Mice

hCD47(Balb/c,2)

Strain Name：BALB/cAnSmoc-Cd47tm2(hCD47)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210359
Validation Data：Presence

The endogenous mice Cd47 gene was replaced by human CD47 gene. While hCD47(BALB/c)(Stock No.NM-HU-2000022) mice function similarly to hCD47(BALB/c,2) mice, for more detailed information please contact our technical advisor.

Mice

hCD20(2)

Strain Name：C57BL/6Smoc-Ms4a1tm3(hCD20)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200114
Validation Data：Presence

Extracellular and transmembrane region of the endogenous mouse Ms4a1 gene was replaced by corresponding region of human CD20 gene. While hCD20(Stock No.NM-HU-190068) mice function similarly to hCD20(2) mice,for more detailed information please contact our technical advisor.

Mice

Jak2-Flox-V617F

Strain Name：C57BL/6Smoc-Jak2tm1(Flox-V617F)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210367

These mice carry a V617F conditional mutation of Jak2 gene. While Jak2-Flox-V617F(2)(Stock No.NM-KI-220009) mice function similarly to Jak2-flox-V617F mice, for more detailed information please contact our technical advisor.

Mice

hFCRN(2)

Strain Name：C57BL/6Smoc-Fcgrttm2(hFCGRT)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190070
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Fcgrt gene was replaced by human FCGRT gene.While hFCRN(Stock No.NM-HU-00109) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN(2) mice,for more detailed information please contact our technical advisor.

Mice

hB7H4

Strain Name：C57BL/6Smoc-Vtcn1tm1(hVTCN1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190004

This VTCN1 humanized mouse model was established by replacing the mouse Vtcn1 gene with the human VTCN1. While hB7H4(2)(Stock No.NM-HU-190075) mice function similarly to hB7H4 mice,for more detailed information please contact our technical advisor.

Mice

hOX40L

Strain Name：C57BL/6Smoc-Tnfsf4tm1(hTNFSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00070

The endogenous mouse Tnfsf gene was replaced by human TNFSF4（OX-40L） gene . While hOX40L(2)(Stock No.NM-HU-200005) mice function similarly to hOX40L mice,for more detailed information please contact our technical advisor.

Mice

Prom1-CreERT2

Strain Name：C57BL/6Smoc-Prom1em1(CreERT2-PolyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200169
Validation Data：Presence

A CreERT2-PolyA expression cassette was knocked into the Prom1 gene start codon site. Prom1 encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. When these Prom1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Prom1 expressing cells.

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