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Models

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Mice

Tacr3-KO

Strain Name：C57BL/6Smoc-Tacr3em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190607

Exon 2-3 of Tacr3 gene was deleted to generate Tacr3 knockout mice.

Mice

F9-KO

Strain Name：C57BL/6Smoc-F9em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18046

The F9 gene is located on the X chromosome. In this F9 knockout mouse model, gRNAs were designed targeting Exon8 of F9 gene via CRISPR gene editing technology. Loss of F9 caused coagulopathy in mice. Mice that are homozygous for F9 knockout are viable, fertile and normal in size. Normal fighting in the cage may cause bleeding or even death due to massive internal hemorrhaging. After the tail cutting, wounds must be cauterized to prevent homozygous knockout mice from blood loss and death. This strain is a powerful model for studying coagulopathy, gene therapy methods and function of factor IX mutations. F9-KO mice (Stock No.NM-KO-18046）carry a knockout allele derived from the targeted deletion of exon 8. While F9-KO(2) mice (Stock No.NM-KO-200607) carrying the exon 1-8 deletion.

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

Il17ra-Flox

Strain Name：C57BL/6Smoc-Il17raem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200103

These mice carry loxP sites flanking exon 2-3 of Il17ra gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Il17ra gene.

Mice

Ninj1-KO

Strain Name：C57BL/6Smoc-Ninj1em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200615

Exon 2 of Ninj1 gene was deleted to generate Ninj1 knockout mice.

Mice

Klb-Flox

Strain Name：B6;129S-Klbtm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00135

These Klb flox mice possess loxP sites flanking exons 2 via ESC targeting. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

hCCR8(2)

Strain Name：C57BL/6Smoc-Ccr8em3(hCCR8)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000054

The endogenous mouse Ccr8 gene was replaced by human CCR8 gene. While hCCR8(Stock No.NM-HU-190053) mice function similarly to hCCR8(2) mice,for more detailed information please contact our technical advisor.

Mice

hVEGFA(2)

Strain Name：C57BL/6Smoc-Vegfaem1(hVEGFA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204984

The endogenous mice Vegfa gene was replaced by human VEGFA gene. While hVEGFA(Stock No.NM-HU-2000028) mice function similarly to hVEGFA(2) mice,for more detailed information please contact our technical advisor.

Mice

hSOST(2)

Strain Name：C57BL/6Smoc-Sostem1(hSOST)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215021

The endogenous mice Sost gene was replaced by human SOST gene. While hSOST(Stock No.NM-HU-200251) mice function similarly to hSOST(2) mice, for more detailed information please contact our technical advisor.

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