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Models

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Mice

hIL17RA

Strain Name：C57BL/6Smoc-Il17ratm1(hIL17RA)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190049

The endogenous mouse Il17ra gene was replaced by human IL17RA gene.

Mice

hIL4

Strain Name：C57BL/6Smoc-Il4tm3(hIL4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190071

The endogenous mouse Il4 gene was completely or partially replaced by human IL4 gene via ESC targeting.

Mice

hPD-1/hCD27(2)

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd27tm2(hCD27)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000096

hPD-1(NM-HU-00015) was crossed with hCD27(2)(NM-HU-190035) to generate hPD-1/hCD27(2).

Mice

R26-CAG-hFcRn

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00081

A human FCGRT expression cassette was knocked in mouse Rosa26 loci.

Mice

hIL6

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18017

This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting.

Mice

Taz-Flox

Strain Name：C57BL/6Smoc-Tazem2(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200001

These mice carry loxP sites flanking exon5-10 of Taz gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Taz gene.

Mice

hTLR8/Lyz2-DTREGFP

Strain Name：C57BL/6Smoc-Lyz2em3(IRES-DTREGFP)Tlr8tm2(TLR8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200259

NM-KI-190041 was crossed with NM-HU-190044 to generate hTLR8/Lyz2-IRES-DTREGFP mice.

Mice

hPD-L1/hCD28

Strain Name：C57BL/6Smoc-Cd274em1(hPD-L1)Cd28em2(hCD28)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210019

hPD-L1(NM-HU-00062) was crossed with hCD28(NM-HU-190011) to generate hPD-L1/hCD28 mice

Mice

hPD-L1/h4-1BB(2)

Strain Name：C57BL/6Smoc-Cd274em1(hPD-L1)Tnfrsf9tm2(h4-1BB)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200260

hPD-L1(NM-HU-00062) was crossed with h4-1BB(2)(NM-HU-190077) to generate hPD-L1/h4-1BB(2).

Mice

hHER2

Strain Name：C57BL/6Smoc-Erbb2tm1(hERBB2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200115

The endogenous mouse Erbb2 gene was replaced by human ERBB2 gene.

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