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Models

About 355 results
Mice

hLY96

Strain Name：C57BL/6Smoc-Ly96tm1(hLY96)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210003
Validation Data：Presence

The endogenous mice Ly96 gene was replaced by human LY96 gene

Mice

h4-1BB(2)/hCD3E(2)

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Cd3etm2(hCD3E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210409

h4-1BB(2)(NM-HU-190077) was crossed with hCD3E(2)(NM-HU-210023)to generate h4-1BB(2)/hCD3E(2) mice.

Mice

hOX40/hCTLA-4

Strain Name：C57BL/6Smoc-Tnfrsf4tm3(hTNFRSF4)Ctla4tm1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00105

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hICOS/hICOSL

Strain Name：C57BL/6Smoc-Icosltm1(hICOSLG) Icostm1(hICOS)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18018
Validation Data：Presence

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111
Validation Data：Presence

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence  |  Publications：1piece

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

hCD147

Strain Name：C57BL/6Smoc-Bsgtm1(hBSG)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000021
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Bsg gene was replaced by human BSG gene.

Mice

Rag2/IL2rg-KO/hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Rag2em1Il2rgem1Sirpatm1(hSIRPA)Cd47tm1(hCD47)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000019

The Rag2 and Il2rg genes of the hSIRPA(2)/hCD47 mouse were deleted.

Mice

hCCR8(2)

Strain Name：C57BL/6Smoc-Ccr8tm3(hCCR8)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000054
Validation Data：Presence

The endogenous mouse Ccr8 gene was replaced by human CCR8 gene. While hCCR8(Stock No.NM-HU-190053) mice function similarly to hCCR8(2) mice,for more detailed information please contact our technical advisor.

Mice

hC1S

Strain Name：C57BL/6Smoc-C1s1tm1(hC1S)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000077
Validation Data：Presence

The endogenous mouse C1s1 gene was replaced by human C1S gene.

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