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Models

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Mice

hIL18

Strain Name:C57BL/6Smoc-Il18tm1(hIL18)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210038
Validation Data:Presence

The endogenous mice Il18 gene was replaced by human IL18 gene.

Mice

hIL2RG/hIL2RB

Strain Name:C57BL/6Smoc-Il2rgtm1(IL2RG)Il2rbtm1(hIL2RB)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210354
Validation Data:Presence

hIL2RG(NM-HU-200007) was crossed with hIL2RB(NM-HU-2000055) to generate hIL2RG/hIL2RB mice.

Mice

hPD-L1(2)/hCD28

Strain Name:C57BL/6Smoc-Cd274tm2(hPD-L1)Cd28tm2(hCD28)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210370

hPD-L1(2)(NM-HU-190039) was crossed with hCD28(NM-HU-190011)to generate hPD-L1(2)/hCD28 mice

Mice

hFOXP2

Strain Name:C57BL/6Smoc-Foxp2tm1(hFOXP2)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210002

The endogenous mice Foxp2 gene was replaced by human FOXP2 gene

Mice

hSIRPA(2)/hCD47/hCTLA-4

Strain Name:C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Ctla4tm1(hCTLA4) Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210368

hCTLA4(NM-HU-00014) was crossed with hSIRPA(2)/hCD47(NM-HU-2000111)to generate hSIRPA(2)/hCD47/hCTLA4 mice

Mice

hSIRPA(2)/hCD47/hPD-1/hPD-L1

Strain Name:C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Pdcd1tm1(hPDCD1)Cd274tm1(hPD-L1)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210358

hSIRPA(2)(NM-HU-18015),hCD47(NM-HU-00050), hPD-1(NM-HU-00015), hPD-L1(NM-HU-00062)was crossed together to generate hSIRPA(2)/hCD47/hPD-1/hPD-L1 mice.

Mice

hHLA-E

Strain Name:C57BL/6Smoc-Igs2tm1(hHLA-E)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-200221

The endogenous human HLA-E gene (about 11kb) was knocked into the H11 locus via CRISPR/Cas9 mediated recombination.

Mice

hHLA-DPA1*03: 01

Strain Name:C57BL/6Smoc-H2-Aatm1(hHLA-DPA1*03: 01)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-210009
Validation Data:Presence

The endogenous mice H2-Aa gene was replaced by human HLA-DPA1*03: 01 gene

Mice

R26-CAG-LSL-hMET-IRES-Luc-2A-tdTomato

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-c-MET-IRES-luciferase-2A-tdTomato)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-18052

A SA-2xpolyA-CAG-Loxp-Stop-Loxp-human cMET-IRES-luciferase-2A-tdTomato-wpre-polyA cassette was knocked into the mouse Rosa26 locus . This strain of mice can be mated with mice expressing Cre recombinase so that human C-MET could be expressed after exposure to Cre recombinase.

Mice

R26-LSL-hEZH2-IRES-Luc-2A-tdTomato

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-EZH2-IRES-luciferase-2A-tdTomato)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-18053

A SA-2xpolyA-CAG-Loxp-Stop-Loxp-human EZH2 cDNA-IRES-luciferase-2A-tdTomato-wpre-polyA cassette was knocked into the mouse Rosa26 locus . This strain of mice can be mated with mice expressing Cre recombinase so that human EZH2 could be expressed after exposure to Cre recombinase.

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