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Models

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Mice

Prkar1a-Flox

Strain Name：C57BL/6Smoc-Prkar1atm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-240915

These strains carry loxP sites flanking exon 3 of Prkar1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Prkar1a gene.

Mice

Tlr7-KO

Strain Name：C57BL/6Smoc-Tlr7em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190166

This Tlr7 knockout mouse model was generated by knocking out the exon 3 region of the Tlr7 .

Mice

Ace2-2A-CreERT2

Strain Name：C57BL/6Smoc-Ace2em2(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200187

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ace2 gene stop codon site. Ace2 encodes angiotensin I converting enzyme 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful for studying lung injury and kidney disease caused by SARS coronavirus infection.

Mice

hAPOE4

Strain Name：C57BL/6Smoc-Apoetm2(hAPOE4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190002

This APOE4 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE4 corresponding sequence by homologous recombination.

Mice

hAppNL-G-F

Strain Name：C57BL/6Smoc-Apptm3(hAppNL-G-F)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000088

The endogenous mouse App gene was replaced by human AppNL-G-F.

Mice

hAppNL-F

Strain Name：C57BL/6Smoc-Apptm3(hAppNL-F)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000087

The endogenous mouse App gene was replaced by human AppNL-F.

Mice

hTREM2

Strain Name：C57BL/6Smoc-Trem2em4(hTRem2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000083

The endogenous mouse Trem2 gene was replaced by human TREM2 gene.

Mice

hAPOE3

Strain Name：C57BL/6Smoc-Apoetm3(hAPOE3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190003

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.

Mice

Sidt2-Flox

Strain Name：B6;129S-Sidt2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00041

The Sidt2 flox allele has loxP sites flanking exon 2 of Sidt2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Snca-KO

Strain Name：C57BL/6Smoc-Sncaem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190380

This Snca knockout mouse model was generated by knocking out the exon4 region of the Snca.

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