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Models

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Mice

MHC Class II (I-A/I-E) -KO

Strain Name：C57BL/6Smoc-H2-Ab1em1H2-Aaem1 H2-Eb1em1H2-Eb2em1H2-Ea-ps em1 Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18032
Validation Data：Presence

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

Syn1-KO

Strain Name：C57BL/6Smoc-Syn1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191042

Exon 4 of Syn1 gene was deleted to generate Syn1 knockout mice.

Mice

ICR

Strain Name：ICR
Strain State：Repository Live | Cat. NO.：SM-006
Validation Data：Presence

ICR

Mice

BALB/c

Strain Name：BALB/cAnSmoc
Strain State：Repository Live | Cat. NO.：SM-003

BALB/c is one of the most widely used inbred lines in biomedical research, especially in immunology and infectious disease research. The incidence of breast tumors is about 10% to 20%. There is a certain number of ovarian, adrenal, pulmonary tumors, and leukemia that occurs. Lung cancer occurs in 26% of female mice and 29% of male mice. The incidence of leukemia is 12% in females and 10% in males. Blood pressure was the highest compared to other inbred mice and had spontaneous hypertension.

Mice

huPBMC-(NMG)

Strain Name：huPBMC-(M-NSG)
Strain State：Repository Live | Cat. NO.：NM-NSG-015

NMG mice are injected with human peripheral blood mononuclear cells (huPBMCs).

Mice

Icosl-Flox

Strain Name：C57BL/6Smoc-Icoslem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200330

These mice carry loxP sites flanking exon 2-3 of Icosl gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Icosl gene.

Mice

Ldlr-C223R

Strain Name：C57BL/6Smoc-Ldlrem1(C223R)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00043

These mice carry a C223R mutation in Ldlr gene via CRISPR/Cas mediated recombination.

Mice

R26-CAG-LSL-hTM6SF2*E167K-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200017

These mice harbor a SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

Mice

Pnpla3-I148M

Strain Name：C57BL/6Smoc-Pnpla3em1(I148M)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200185

These mice carry a I148M mutation of Pnpla3 gene.

Mice

huHSC-(NMG)

Strain Name：huHSC-(M-NSG)
Strain State：Repository Live | Cat. NO.：NM-NSG-017
Publications：2piece

After irradiation, NMG mice are injected with CD34+ hematopoietic stem cells (CD34+ HSC).

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