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Models

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Mice

MHC Class II(I-A/I-E)-KO(Nod-Scid)

Strain Name：NOD-PrkdcscidH2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-psem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-18057

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

MHC ClassII(I-A/I-E)-KO(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1Smoc
Strain State：Developing | Cat. NO.：NM-NSG-003

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.  These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

MHC Class II (I-A/I-E) -KO

Strain Name：C57BL/6Smoc-H2-Ab1em1H2-Aaem1 H2-Eb1em1H2-Eb2em1H2-Ea-ps em1 Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18032

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

Tbx21-KO

Strain Name：C57BL/6Smoc-Tbx21em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190157

This Tbx21 knockout mouse model was generated by knocking out the exon 2 region of the Tbx21.

Mice

Akt3-KO

Strain Name：C57BL/6Smoc-Akt3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-191091

Exon 3-5 of Akt3 gene was deleted to generate Akt3 knockout mice.

Mice

Kras-LSL-G12D

Strain Name：C57BL/6Smoc-Krasem4(LSL-G12D)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190003

exon2 of Kras were replaced by loxp-stop-loxp and exon2 containing G12D. When crossed with a Cre recombinase-expressing strain, this strain is useful in studies of cancer and development.

Mice

Nf2-Flox

Strain Name：C57BL/6Smoc-Nf2tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200017

These mice carry loxP sites flanking exon 2 of Nf2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nf2 gene.

Mice

Txlna-KO

Strain Name：C57BL/6Smoc-Txlnaem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00123

Exon1 of Txlna gene was deleted to generate Txlna knockout mice.

Mice

Frat1-KO

Strain Name：C57BL/6Smoc-Frat1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190676

Exon 1 of Frat1 gene was deleted to generate Frat1 knockout mice.

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