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Mice

Mnx1-IRES-Cre

Strain Name：C57BL/6Smoc-Mnx1em1(IRES-Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200010
Validation Data：Presence

A IRES-Cre-WPRE-polyA expression cassette was knocked into the Mnx1 gene stop codon site. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Mnx1. These mice may be useful for studying spinal muscular atrophy (SMA).

Mice

R26-CAG-LSL-hNRF2-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-NRF2-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18050

A SA-2xpolyA-CAG-LSL-human NRF2-IRES-luciferase-2A-tdTomato-wpre-polyA cassette was knocked into the mouse Rosa26 locus . This strain of mice can be mated with mice expressing Cre recombinase to express human NRF2 and a reporter gene in certain cells or tissues that expressing Cre recombinase.

Mice

Nkx2-1-CreERT2

Strain Name：C57BL/6Smoc-Nkx2-1em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200123
Validation Data：Presence

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

Mice

Coll1a1-pTRE-Msi1/Krt14-rtTA

Strain Name：Coll1a1-pTRE-Msi1/Krt14-rtTA
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210411

Expression of the Msi1 gene can be regulated by the tetracycline analog, doxycycline (dox); in the presence of dox, transcription of the Msi1 gene is induced in cells where rtTA is expressed.

Mice

Pdyn-IRES-Cre

Strain Name：C57BL/6Smoc-Pdynem1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200089
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Pdyn gene stop codon site. Pdyn encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying depression, stress, anxiety, pain response, circadian rhythm and appetite control.

Mice

Vip-IRES-Cre

Strain Name：C57BL/6Smoc-Vipem1(IRES-iCre-SV40-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200100
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Vip gene stop codon site. Vip encodes vasoactive intestinal polypeptide. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in cells expressing. This strain is useful for studying bronchiectasis, immunomodulatory and anti-inflammatory.

Mice

Calb2-IRES-Cre

Strain Name：C57BL/6Smoc-Calb2em1(IRES-iCre-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200102
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Calb2 gene stop codon site. Calb2 gene encodes calbindin 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. The protein plays a key role in the nervous system.

Mice

Avp-IRES-Cre

Strain Name：C57BL/6Smoc-Avpem1(IRES2-Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200142
Validation Data：Presence

A IRES2-Cre-WPRE-polyA expression cassette was knocked into the Avp gene stop codon site. Avp encodes arginine vasopressin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying hypertension.

Mice

Csf2rb2-2A-Cre

Strain Name：C57BL/6Smoc-Csf2rb2em1(2A-Cre)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210001
Validation Data：Presence

2A-Cre expression cassette was knocked into the Csf2rb2 gene. Csf2rb2 is also known as colony stimulating factor 2 receptor. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. The gene product has been involved in the modulation of memory.

Mice

Calb1-2A-GFPCre

Strain Name：C57BL/6Smoc-Calb1em1(2A-EGFP-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200141
Validation Data：Presence

A 2A-EGFP-Cre expression cassette was knocked into the Calb1 gene stop codon site. Calb1 is highly expressed in the brain. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful in studying many neurobehavioral diseases such as spatial learning and circadian rhythm interference. It has been reported that the incidence of many diseases may be different between genders.

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