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Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001

Prkdc and Il2rg genes were both knocked-out in NOD mice.  Lacking mature T, B and NK cells Low immune rejection against human cells and tissues Good tumorigenicity so that a small number of cells can form tumors. Significant improvement in the survival of transplanted human cells and tissues Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models Suitable as the carrier mice for the transplantation of heterologous cells and tissues

Mice

NOD SCID

Strain Name：NOD.Cg-Prkdcscid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019

The scid mutation has been transferred onto a diabetes-susceptible Non-Obese Diabetic (NOD) background. NOD-Scid mice do not develop diabetes, lack T and B cells, and are inherently immune deficient, making them good recipients for transplantation of human hematopoietic stem cells and human solid tumors. 

Mice

Atp4b-IRES-CreERT2(2)

Strain Name：C57BL/6Smoc-Atp4bem2(IRES-CreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210119

An IRES-CreERT2 expression cassette was knocked into the Atp4b gene stop codon site. Besides,An IRES-CreERT2-WPRE-pA expression cassette were knock into the Atp4b gene start codon site to generate Atp4b-IRES-CreERT2(Stock No. NM-KI-210118) mice. ATP4B could serve as a tumor suppressor in the tumorigenesis and progression. This strain is useful in studying the function of gastric parietal cells in gastric epithelial homeostasis. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cre-expressing cells after tamoxifen treatment.

Mice

Tnfrsf1a/Tnfrsf1b-KO

Strain Name：C57BL/6Smoc-Tnfrsf1aem1Smoc Tnfrsf1aem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18036

This strain is also called p55/p75-KO. The Tnfrsf1a and Tnfrsf1b double knockout mouse models were obtained by knocking out both exon 2-5 region of mouse Tnfrsf1a gene and exon2 of mouse Tnfrsf1b gene. Tnfrsf1a and Tnfrsf1b deletion (p55 and p75 deficiency) homozygous mice are viable and fertile, and these homozygous mice fail to bind TNF (tumor necrosis factor).

Mice

Cav1-KO

Strain Name：C57BL/6Smoc-Cav1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190930

Exon 3 of Cav1 gene was deleted to generate Cav1 knockout mice.

Mice

Clu-KO

Strain Name：C57BL/6Smoc-Cluem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190782

Exon 3 of Clu gene was deleted to generate Clu knockout mice.

Mice

Eif4ebp1-KO

Strain Name：C57BL/6Smoc-Eif4Ebp1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-191088

Exon 1 of Eif4ebp1 gene was deleted to generate Eif4ebp1 knockout mice.

Mice

Eif4e-KO

Strain Name：C57BL/6Smoc-Eif4Eem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191115

Exon 4-5 of Eif4e gene was deleted to generate Eif4e knockout mice.

Mice

Ppp2cb-KO

Strain Name：C57BL/6Smoc-Ppp2Cbem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191016

Exon 4-6 of Ppp2cb gene was deleted to generate Ppp2cb knockout mice.

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