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Humanized Mice

NMG and NMG-B2m mice transplanted with human-derived PBMC are suitable for short-term in vivo tests requiring mature T cell function, including studies on HIV infection, immuno-oncology and GvHD.

Humanized Mice

NMG mice with human-derived CD34+ hematopoietic stem cells can be used for reconstruction of multi-lineage human immune cells, and represent effective model animals for studies on immuno-oncology and infectious diseases.

Why IL-2 Still Holds Promise in Therapeutics of Cancer and Autoimmunity

Services

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Shanghai Model Organisms offers a full range of model organism services, including model customization services, research-ready models, breeding, phenotyping and drug screening. Mouse, rat, zebrafish and C. elegans models are available to meet different research needs.

GEMM-Derived Allografts

Smad4 CKO Mouse Model

Our own-developed Smad4 conditional knockout mice (Smad4-CKO) can be used to study cell proliferation and tumor suppression.

P53 CKO Mouse Model

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Our own-developed mouse model of p53 conditional knockout (p53-CKO) can be mated with mice carrying tissue-specific Cre expression to obtain mice with homozygous deletion of p53 in specific tissues or cells. These mice can be used for tumorigenesis and tumor mechanistic studies.

Pten CKO Mouse Model

Our own-developed mouse model of Pten conditional knockout (Pten-CKO) can be mated with mice carrying tissue-specific Cre expression to obtain mice with homozygous deletion of Pten in specific tissues or cells, thus avoiding the embryonic death caused by systemic and homozygous Pten knockout. Pten-CKO mice can be used to study tumorigenesis, anti-tumor targets, neurogenesis, glial differentiation and cerebellar development.

Surgical & Preconditioning Services

Rb1 CKO Mouse Model

With the ability to avoid the risk of death caused by homozygous and systemic knockout, our own-developed Rb1 conditional knockout mice (Rb1-CKO) can be used to study cancer, cell cycle or aging.