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Drd1-Flox

Strain Name：C57BL/6Smoc-Drd1^{em1(flox)Smoc}
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200159

These mice carry loxP sites flanking exon 2 of Drd1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Drd1 gene.

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1^{tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc}
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2^{tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc}
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Htr1a-KO

Strain Name：C57BL/6Smoc-Htr1A^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190594

Exon 1 of Htr1a gene was deleted to generate Htr1a knockout mice.

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These Mice Are About to Go Viral Because of the Nobel Prize!

microRNA (miRNA) microRNA mouse models Nobel Prize microRNA discovery genetically engineered mice miRNA in gene regulation miRNA therapeutics miRNA in cancer research customized mouse models contract research organization (CRO) preclinical drug discovery

The 2024 Nobel Prize in Physiology or Medicine awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) highlights its revolutionary role in gene regulation and disease treatment. This article explores miRNA's impact on neuroscience, cancer, and cardiovascular research. GenoBioTX offers advanced microRNA mouse models and customized genetic solutions, empowering researchers with essential tools to drive innovation in miRNA studies and therapeutic developments.

Pathological Analysis

Pathological analysis H&E staining

Shanghai Model Organisms can analyze morphological and pathological changes in various animal tissues.

Phenotyping

mouse phenotype mouse phenotype database gene phenotype

Provide blood analysis, image analysis, pathology analysis, behavior analysis etc.

表現型分析

血液検査、画像分析、組織病理形態学的分析、行動学的研究、代謝学的分析などを提供することができます。