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Cdkn2a-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg

Strain Name：C57BL/6Smoc-Cdkn2a^em3(flox)Krase^m4(LSL-G12D)Tg(Pdx1-Cre)^Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-XA-234942

The Cdkn2a-Flox(p16/p19-Flox) was crossed with Kras-LSL-G12D/Pdx1-Cre-Tg to generate Cdkn2a-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg mice.

Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg

Strain Name：C57BL/6Smoc-Smad4^tm1(flox)Kras^{em4(LSL-G12D)}Tg(Pdx1-Cre)^Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-XA-234939

The Smad4-Flox was crossed with Kras-LSL-G12D/Pdx1-Cre-Tg to generate Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg mice.

Kras-LSL-G12D/Trp53-Flox-R172H/Pdx1-2A-Cre

Strain Name：C57BL/6Smoc-Krase^m4(LSL-G12D)Trp53^{tm(flox-R172H)}Pdx1^{em(2A-Cre)1Smoc}
Strain State：Developing | Cat. NO.：NM-XA-242420

The Kras-LSL-G12D/Trp53-Flox-R172H(NM-XA-242419) was crossed with Pdx1-2A-Cre(NM-KI-225082) to generate Kras-LSL-G12D/Trp53-Flox-R172H/Pdx1-2A-Cre mice.

Pdhx-Flox

Strain Name：C57BL/6Smoc-Pdhx^{em1(flox)Smoc}
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Pdhx gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pdhx gene.

Pdhx-KO

Strain Name：C57BL/6Smoc-Pdhx^em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 2-3 of Pdhx gene was deleted to generate Pdhx knockout mice.

KPC(3)

Strain Name：C57BL/6Smoc-Kras^{em4(LSL-G12D)}Trp53^{tm(LSL-R172H)}Tg(Pdx1-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-234804

The Kras-LSL-G12D/Pdx1-Cre-Tg was crossed with Trp53-LSL-R172H to generate KPC(3) mice.

Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg

Strain Name：Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg
Strain State ： 成瘤验证完成 |  Cat. NO.：NM-YD13

Derived from Smad4-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg mice(NM-XA-234939) spontaneous lung cancer model

KPC(R270H)

Strain Name：KPC(R270H)
Strain State ： Construction completed |  Cat. NO.：NM-YD11

The KPC(R270H) cell line was derived from the KPC(2) mice(NM-KI-220014)

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Liver Cancer PDX Model

PDX PDX models Patient-derived Xenografts

Patient-derived Xenografts (PDX) are advanced preclinical oncology models for drug development. It offers a far better alternative for preclinical drug evaluation as compared to the conventional cell line-derived xenograft model.