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Genotyping Analysis

Fibrosis

liver fibrosis model

The mouse liver fibrosis model can be generated by surgery or drug induction, which can be used to study the role of genes and proteins in the development of liver fibrosis, to explore the mechanisms underlying liver fibrosis, and to carry out drug efficacy evaluations.

Excision and Regeneration of Tissue

liver regeneration subtotal gastrectomy

A mouse tissue regeneration model can be established by an operation of partial tissue excision. Such models can be used to study the changes in morphology, serology and metabolism during tissue regeneration, and hence lay the experimental foundation for studying the mechanisms regulating tissue regeneration.

How to Verify Your Cre-lox Model

Breeding Services

We will delivery the specific genotype model product within specific period by natural breeding or assisted reproduction technology. The specified breeding technologies include natural breeding, assisted reproduction, SPF purification, etc.

モデルマウスの繁殖

カスタマイズされた後のモデル、またはお客様の既有の遺伝子組み換え動物モデルは、自然繁殖または補助的生殖繁殖の方法によって、特定周期に、特定遺伝子型モデル製品として提供されます。具体的には、自然繁殖、補助的生殖繁殖、 SPF精製等が含まれます。

모델 번식

특정 유전자 조합 모델 상품을 자연 번식 혹은 보조 생식하여 특정 시기에 납품됩니다. 이미 고객님이 보유한 유전자 변형 동물 모델 또한 자연 번식 혹은 보조 생식 서비스를 제공합니다.구체적 번식 기술: 자연 번식, 보조 생식, SPF 정화 등.

Osteoporosis

osteoporosis gene osteoporosis diseases Tnfrsf11b

Tnfrsf11b (Opg) knockout mice were generated through homologous recombination and supplied by Shanghai Research Center for Model Organisms. This mouse model, which is referred to as the "osteoporotic mouse", shows a typical phenotype of osteoporosis and arterial calcification, and Therefore, this animal model is ideal for drug screening and evaluation for the treatment of "human osteoporosis", in gene therapy of osteoporosis, as well as in the research on the mechanisms of interaction between osteoclasts and osteoblasts.

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.