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Gene Knock-in

gene knock in knock in mice knock in mouse

Knock-in represents the introduction of specific mutations or exogenous genes, such as point mutations (mimicking human genetic disease) at the selected location or reporter genes (e.g., EGFP, RFP, mCherry, YFP, LacZ, Luciferase etc.) or functional cDNAs (such as Cre, Dre etc.) into a specific genomic locus through homologous recombination, thereby allowing the exogenous DNA fragment to be expressed. A simultaneous occurrence of knock-in and knock-out can be achieved by replacing a murine endogenous gene with a foreign DNA fragment.

Behavioral Analysis

study of animal behavior behavioral analysis

Shanghai Model Organisms' rodent behavioral analysis platform is equipped with a variety of experimental instruments used to study the classical behaviors of mice. Shanghai Model Organisms can provide single-item or complete sets of mouse behavioral analysis to assist you with your research in neurology, physiology, drug development, and drug efficacy evaluation. The Noldus behavioral analysis system is used to more comprehensively and accurately reflect the neurological and mental states of mice.

Osteoporosis

osteoporosis gene osteoporosis diseases Tnfrsf11b

Tnfrsf11b (Opg) knockout mice were generated through homologous recombination and supplied by Shanghai Research Center for Model Organisms. This mouse model, which is referred to as the "osteoporotic mouse", shows a typical phenotype of osteoporosis and arterial calcification, and Therefore, this animal model is ideal for drug screening and evaluation for the treatment of "human osteoporosis", in gene therapy of osteoporosis, as well as in the research on the mechanisms of interaction between osteoclasts and osteoblasts.

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Metabolic Analysis

Metabolic analysis

There are many mice models used to mimic human metabolic diseases, such as diabetes and obesity, which are caused by nutritional imbalances and metabolic disorders. The detection and analysis of sugar and lipid metabolism phenotypes in these model mice are crucial for the establishment of model mice, the study of disease progression, and the research on the pathogenesis. Shanghai Model Organisms can help your research on metabolism by providing you with a series of testing tools for glucose and lipid metabolisms.