Welcome to Advanced Search

Mrc2-KO

Strain Name：C57BL/6Smoc-Mrc2^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190216

This Mrc2 knockout mouse model was generated by knocking out the exon3-8 region of the Mrc2.

hSLAMF7

Strain Name：C57BL/6Smoc-Slamf7^{em(hSLAMF7)Smoc}
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18028

The endogenous mouse Slamf7 gene was replaced by human SLAMF7 gene .

Arc-CreERT2

Strain Name：C57BL/6Smoc-Arc^{em1(CreERT2-SV40-pA)Smoc}
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200101

A CreERT2 expression cassette was knocked into the Arc gene start codon site.

These Mice Are About to Go Viral Because of the Nobel Prize!

microRNA (miRNA) microRNA mouse models Nobel Prize microRNA discovery genetically engineered mice miRNA in gene regulation miRNA therapeutics miRNA in cancer research customized mouse models contract research organization (CRO) preclinical drug discovery

The 2024 Nobel Prize in Physiology or Medicine awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) highlights its revolutionary role in gene regulation and disease treatment. This article explores miRNA's impact on neuroscience, cancer, and cardiovascular research. GenoBioTX offers advanced microRNA mouse models and customized genetic solutions, empowering researchers with essential tools to drive innovation in miRNA studies and therapeutic developments.

SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.

CKO mice developed by SMOC supported the identification of a novel lncRNA that regulates dendritic cell migration and the corresponding immune response

CKO mice lncRNA dendritic cell

Join Our Webinar: Applications of Humanized Mouse Models in Preclinical Research

Humanized mouse models preclinical research targeted therapies webinar oncology drug development preclinical therapeutic advancements immune system models animal modeling services

Join GenoBioTX's webinar on July 25th to explore the latest advancements in humanized mouse models for preclinical research. Learn how these models are transforming targeted therapy development across various diseases. Featuring expert insights from Dr. Derek Reznik, discover the generation and application of humanized immune system models in oncology drug development. Don't miss this opportunity to enhance your knowledge in cutting-edge preclinical therapeutic advancements. Register now!

We Will Be Attending AACR 2023 in Orlando!

Mouse

transgenic mice mouse model editing mouse

Mice have long been the prime choice for model organisms. In more than 100 years, mice have been widely used by researchers in the fields of physiology, pathology, pharmacology, toxicology, and behavioral science. With the establishment of gene targeting technology, many researchers have made their way to the Nobel Prize.

In Vivo Efficacy Evaluation