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Models

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Mice

hCALCRL

Strain Name:C57BL/6Smoc-Calcrlem1(hCALCRL)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-225031

The endogenous mouse Calcrl gene was replaced by human CALCRL gene.

Mice

hCB1

Strain Name:C57BL/6Smoc-Cnr1em1(hCB1)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-225027

The endogenous mouse Cnr1 gene was replaced by human CB1 gene.

Mice

hSTING

Strain Name:C57BL/6Smoc-Tmem173tm2(hTMEM173)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190036

The endogenous mouse Tmem173 gene was replaced by human TMEM173 gene.

Mice

hCD79A(BALB/c)

Strain Name:BALB/cAnSmoc-Cd79aem1(hCD79A)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-241168

The endogenous mouse Cd79a gene was replaced by human CD79A gene.

Mice

hTNFR2

Strain Name:C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190010

The endogenous mouse Tnfrsf1b gene was replaced by human TNFRSF1B gene.

Mice

KPC

Strain Name:C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-210096

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Mice

hTREM2

Strain Name:C57BL/6Smoc-Trem2em4(hTRem2)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000083

The endogenous mouse Trem2 gene was replaced by human TREM2 gene.

Mice

hOX40

Strain Name:C57BL/6Smoc-Tnfrsf4em1(hTNFRSF4)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-00041

The endogenous mouse Tnfrsf4(Ox40) gene was replaced by human TNFRSF4(OX40) gene. While hOX40(2)(Stock No.NM-HU-00078) mice function similarly to hOX40 mice,for more detailed information please contact our technical advisor.

Mice

hLAG3

Strain Name:B6.129S-Lag3tm1(hLAG3)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00049

The endogenous mouse Lag3 gene exon1-7 was replaced by human LAG3 gene extracellular region by homologous recombination.

Mice

hCX3CR1

Strain Name:C57BL/6Smoc-Cx3cr1em1(hCX3CR1)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-HU-241954

The endogenous mouse Cx3cr1 gene was replaced by human CX3CR1 gene.

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