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Models

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Mice

HLA-A11.1/B2M(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1B2mtm1(hB2M-linker-HLA-A*1101/H2-D1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-252346
Validation Data：Presence

The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*1101/H2-D1 gene.

Mice

hCRP

Strain Name：C57BL/6Smoc-Crptm1(hCRP)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-242427
Validation Data：Presence

The endogenous mouse Crp gene was replaced by human CRP gene.

Mice

hEGF

Strain Name：C57BL/6Smoc-Egftm1(hEGF)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-241970
Validation Data：Presence

The endogenous mouse Egf gene was replaced by human EGF gene.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence  |  Publications：1piece

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

Flt3-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Flt3em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-234079
Validation Data：Presence

The exon3 of Flt3 gene was deleted to generate Flt3 knockout mouse.

Mice

Il1b-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1bem1(Luc-eGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00010
Validation Data：Presence  |  Publications：2piece

A Luciferase-2A-EGFP-pA cassette was inserted at ATG site of mouse Il1b gene. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1b.

Mice

Tmem164-KO

Strain Name：C57BL/6Smoc-Tmem164em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234906

The exon 4 of Tmem164 gene was deleted to generate Tmem164 knockout mouse.

Mice

Trdc-IRES-CreERT2

Strain Name：C57BL/6Smoc-Trdcem1(IRES-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-231464
Validation Data：Presence

The IRES-CreERT2 expression cassette was inserted after the termination codon of the mouse Trdc gene.

Mice

MHCII/B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1B2m em1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-014

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Mice

R26-CAG-RSR-tdTomato-2A-DTR

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-RSR-tdTomato-2A-DTR)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200191

This mouse was obtained by crossing R26-(CAG-LSL-RSR-tdTomato-2A-DTR) mice with systemic Cre mice.

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