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Models

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Mice

R26-pAPOE-hCYP3A4(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

Mice

R26-LSL-Notch1C-IRES-nEGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-LSL-Notch1C-IRES-nEGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200036

These mice harbor a SA-LSL-Notch1C-IRES-nEGFP cassette in the Rosa26 locus generated by homologous recombination.Notch1C (mouse Notch1 ,amino acids 1749–2293)

Mice

Cdkn2a/Cdkn2b-Flox(p15/p16-Flox)

Strain Name：C57BL/6Smoc-Cdkn2a/Cdkn2bem2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-250099

On the basis of Cdkn2b-Flox(NM-CKO-2115067), a p15/ P16-Flox mouse model was obtained by inserting loxP on both sides of Cdkn2b(p15) gene exon 2 and lox2272 on both sides of Cdkn2a(p16) gene exon1. The flox region of these strains is exon2 of p15 gene and exon1 of p16 gene.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

Cd274-KO(2)

Strain Name：C57BL/6Smoc-Cd274em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18044

Cd274 gene is also called B7-H1, Pdcd1lg1 or PD-L1. The PD-L1-KO(2) mouse model was obtained by deleting the Exon 3-5 region of mouse Cd274 gene. While PD-L1-KO(Stock No.NM-KO-00104) mice have been pulled from shelves for some reasons.

Mice

Mt1-Flox/Mt2-Flox

Strain Name：C57BL/6Smoc-Mt1 em1（flox）Mt2 em1（flox）Smoc
Strain State：Developing | Cat. NO.：NM-CKO-252576

The MT1-FLOX model was constructed based on Mt2-Flox (NM-CKO-226357) by inserting loxP sites on both sides of exon 2-3 of the Mt1 gene respectively. This flox mouse can be mated with tissue-specific Cre tool mice to obtain mouse models with the Mt1 gene knocked out in specific cell types or tissues.

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

pMMTV-Jag1-Tg(Balb/c)

Strain Name：BALB/cAnSmoc-Tg(pMMTV-Jag1)2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-TG-225004

These transgenic mice harbor pMMTV-Jag1 expression cassettes.

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