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Models

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Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

Cd274-KO(2)

Strain Name：C57BL/6Smoc-Cd274em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18044

Cd274 gene is also called B7-H1, Pdcd1lg1 or PD-L1. The PD-L1-KO(2) mouse model was obtained by deleting the Exon 3-5 region of mouse Cd274 gene. While PD-L1-KO(Stock No.NM-KO-00104) mice have been pulled from shelves for some reasons.

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

pMMTV-Jag1-Tg(Balb/c)

Strain Name：BALB/cAnSmoc-Tg(pMMTV-Jag1)2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-TG-225004

These transgenic mice harbor pMMTV-Jag1 expression cassettes.

Mice

Zap70-W163C(Balb/c)

Strain Name：BALB/cAnSmoc-Zap70em(W163C)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210366

These mice carry a W163C mutation of Zap70 gene.

Mice

Foxj1-EGFP-CreERT2

Strain Name：C57BL/6Smoc-Foxj1em1(GFP-CreERT2-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200133

A GFP-CreERT2-polyA expression cassette was knocked into the Foxj1 gene start codon site.

Mice

R26-CAG-LSL-Zbp1-Mouse-L-3xFLAG-bGH

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Kozak-Zbp1-Mouse-L-3xFLAG-WPRE-bGH-pA)Smoc
Strain State：Developing | Cat. NO.：NM-KI-241596

The CAG-LSL-Kozak-Zbp1-Mouse-L-3xFLAG-WPRE-bGH-pA expression cassette was knocked into the R26 locus.

Mice

R26-CAG-FLEX-Zbp1-Mouse-L-3xFLAG

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-loxP-STOP-lox2272-3xFLAG-Zbp1-Mouse-L-Kozak-loxP-lox2272-WPRE-bGH-pA)Smoc
Strain State：Developing | Cat. NO.：NM-KI-250273

The CAG-loxP-STOP-lox2272-3xFLAG-Zbp1-Mouse-L-Kozak-loxP-lox2272-WPRE-bGH-pA expression cassette was knocked into the R26 locus.

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