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Models

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Mice

Mrc2-KO

Strain Name：C57BL/6Smoc-Mrc2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190216

This Mrc2 knockout mouse model was generated by knocking out the exon3-8 region of the Mrc2.

Mice

Tnfrsf11b-KO

Strain Name：C57BL/6Smoc-Tnfrsf11bem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190400

This Tnfrsf11b knockout mouse model was generated by knocking out the exon2 region of the Tnfrsf11b.

Mice

Slco4a1-KO

Strain Name：C57BL/6Smoc-Slco4a1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190376

This Slco4a1 knockout mouse model was generated by knocking out the exon 3 region of the Slco4a1 .

Mice

B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1SmocB2mem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-002

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

Mice

Hc-KO

Strain Name：C57BL/6Smoc-Hcem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190191

This Hc knockout mouse model was generated by knocking out the exon 6 region of the Hc.

Mice

Cdkn2a-KO(p16-KO)

Strain Name：C57BL/6Smoc-Cdkn2aem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-240239

Cdkn2a(p16) gene knockout mouse model was established by knockout exon1 of Cdkn2a-p16INK4a transcript (Cdkn2a-201 transcript).

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

KPC

Strain Name：C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Mice

hIL12B

Strain Name：C57BL/6Smoc-Il12betm3(hIL12B)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000057

The endogenous mouse Il12b gene was replaced by human IL12B gene.

Mice

hIL2RB

Strain Name：C57BL/6Smoc-Il2rbtm1(hIL2RB)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000055

The endogenous mouse Il2rb gene was replaced by human IL2RB gene.

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