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Models

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Mice

Chid1-KO

Strain Name：B6;129S-Chid1tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00029

Targeting vector was designed to delete exons 2-6.

Mice

Inpp4b-KO

Strain Name：C57BL/6Smoc-Inpp4bem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190297

This Inpp4b knockout mouse model was generated by knocking out the exon 11 region of the Inpp4b.

Mice

Ptpn11-Flox

Strain Name：C57BL/6Smoc-Ptpn11em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-231881

These strains carry loxP sites flanking exon 4 of Ptpn11 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ptpn11 gene.

Mice

Ppara-KO

Strain Name：C57BL/6Smoc-Pparaem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190345

This Ppara knockout mouse model was generated by knocking out the exon 4 region of the Ppara.

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

Foxn1-IRES-Cre

Strain Name：C57BL/6Smoc-Foxn1em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200106

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.

Mice

R26-pAPOE-hCYP3A4(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

Mice

C57BL/6

Strain Name：C57BL/6Smoc
Strain State：Repository Live | Cat. NO.：SM-001

C57BL/6 mice have a high reproductive capacity, a long life span, and a low tumor susceptibility. Male mice are aggressive and fight frequently. Diet can cause obesity, type II diabetes, and atherosclerosis in these mice. The C57BL/6 mouse is the first to have its entire genome sequenced. It is the most extensively used inbred mouse strain as a genetic basis for congenic and mutant mice. It is also used in genetics, metabolism, immunology, neurology, behavioral research, pharmacodynamics, and medication safety evaluation.

Mice

Btd-KO

Strain Name：C57BL/6Smoc-Btdem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200630

Exon 2-3 of Btd gene was deleted to generate Btd knockout mice.

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