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Models

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Mice

Ccl3-KO

Strain Name：C57BL/6Smoc-Ccl3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190014

This Ccl3 knockout mouse model was generated by knocking out the exon 2 region of the Ccl3.

Mice

Cd6-KO

Strain Name：C57BL/6Smoc-Cd6em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190043

This Cd6 knockout mouse model was generated by knocking out the exon 3-12 region of the Cd6.

Mice

Tmcc2-KO

Strain Name：C57BL/6Smoc-Tmcc2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190392

This Tmcc2 knockout mouse model was generated by knocking out the exon3 region of the Tmcc2.

Mice

Nod1-KO

Strain Name：C57BL/6Smoc-Nod1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190208

This Mavs knockout mouse model was generated by knocking out the exon3 region of the Mavs.

Mice

KPC

Strain Name：C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Mice

Il6ra-KO

Strain Name：C57BL/6Smoc-Il6raem2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18042

The Il6ra knockout mouse model was obtained by knocking out the exon 2-3 region of mouse Il6ra gene.

Mice

Cd274-KO(2)

Strain Name：C57BL/6Smoc-Cd274em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18044

Cd274 gene is also called B7-H1, Pdcd1lg1 or PD-L1. The PD-L1-KO(2) mouse model was obtained by deleting the Exon 3-5 region of mouse Cd274 gene. While PD-L1-KO(Stock No.NM-KO-00104) mice have been pulled from shelves for some reasons.

Mice

Ccr1-KO

Strain Name：C57BL/6Smoc-Ccr1em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190768

Exon 2 of Ccr1 gene was deleted to generate Ccr1 knockout mice.

Mice

Stat3-Flox

Strain Name：C57BL/6Smoc-Stat3tm7(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200050

These mice carry loxP sites flanking exon 12-14 of Stat3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stat3 gene.While Stat3-Flox(2)(Stock No.NM-CKO-200225）mice carrying the loxP sites flanking exon 18-20 of Stat3 gene.

Mice

Il10ra-Flox

Strain Name：C57BL/6Smoc-Il10raem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200102

These mice carry loxP sites flanking exon 2 of Il10ra gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Il10ra gene.

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