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Models

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Mice

Gpr89/Prkab2-KO

Strain Name：C57BL/6Smoc-Gpr89em1Prkab2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18055

The sgRNAs were designed targeting Gpr89 intron11 and Prkab2 intron7 resulting in a sequence deletion of approximately 790 Kb between the Gpr89 gene and the Prkab2 gene.

Mice

Dgcr2/Hira-KO

Strain Name：C57BL/6Smoc-Dgcr2em1Hiraem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18060

the sgRNAs were designed targeting Dgcr2 intron9 and Hira intron24 resulting in a sequence deletion of approximately 0.11 mb between the Dgcr2 gene and the Hira gene.

Mice

Tcrd-KO

Strain Name：C57BL/6Smoc-Tcrdem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234131

The knockout region is exon 1-4 of the Trdc gene in the constant region of the Tcrd/Tcrδ gene cluster.

Mice

Tcrδ-KO

Strain Name：C57BL/6Smoc-Tcrδem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190435

The knockout region is exon 1-4 of the Trdc gene in the constant region of the Tcrd/Tcrδ gene cluster.

Mice

Tfpi2-Flox

Strain Name：B6;129S-Tfpi2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00117

A loxp-IRES-GFP-reverse loxp cassette and an frt-Neo-frt cassette were inserted in intron 2 of Tfpi2 gene. After crossed with Cre transgenic mice, Tfpi2 gene is supposed to be knocked out and labeled by GFP simultaneously.

Mice

F9-KO

Strain Name：C57BL/6Smoc-F9em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18046
Validation Data：Presence  |  Publications：1piece

The F9 gene is located on the X chromosome. In this F9 knockout mouse model, gRNAs were designed targeting Exon8 of F9 gene via CRISPR gene editing technology. Loss of F9 caused coagulopathy in mice. Mice that are homozygous for F9 knockout are viable, fertile and normal in size. Normal fighting in the cage may cause bleeding or even death due to massive internal hemorrhaging. After the tail cutting, wounds must be cauterized to prevent homozygous knockout mice from blood loss and death. This strain is a powerful model for studying coagulopathy, gene therapy methods and function of factor IX mutations. F9-KO mice (Stock No.NM-KO-18046）carry a knockout allele derived from the targeted deletion of exon 8. While F9-KO(2) mice (Stock No.NM-KO-200607) carrying the exon 1-8 deletion.

Mice

hMASP3

Strain Name：C57BL/6Smoc-Masp1tm1(hMASP3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-231491

The MASP1 gene encodes the MASP3 protein through alternative splicing. This strain was a knock-in model generated by homologous recombination with an hMASP3 cassette at Masp1 gene locus.

Mice

Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA-4

Strain Name：C57BL/6Smoc-Fcgr2bem1Fcgr3em1Fcgr4em1Ctla4em1(hCTLA4)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-220069

The Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA4 mouse model was obtained by deleting all sequences from upstream of Fcgr3 gene to the 3'UTR of Fcgr2b gene in the hCTLA4(NM-HU-00014) mouse.

Mice

Spred1-Flox

Strain Name：C57BL/6Smoc-Spred1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200299

This product was constructed with reference to the literature (PubMed ID: 21668589), in which loxP sites were inserted on both sides of exon 7 in the Spred1 gene transcript ENSMUST00000028829. The floxed region does not encompass the complete transcript ENSMUST00000110901.

Mice

Fnta-KO

Strain Name：C57BL/6Smoc-Fntaem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-226359

Exon 3-5 of Fnta gene was deleted to generate Fnta knockout mice, it is difficult to obtain homozygotes in this strain.

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