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Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025
Publications：1piece

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain also explicitly states that fluorescence cannot be directly observed.

Mice

Bmal1-Flox

Strain Name：C57BL/6Smoc-Bmal1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200063

These mice carry loxP sites flanking exon 8 of Bmal1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bmal1 gene.

Mice

Hif1a-Flox

Strain Name：C57BL/6Smoc-Hif1atm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190065
Publications：1piece

These mice carry loxP sites flanking exon 2 of Hif1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Hif1a gene.

Mice

Pdcd1-Flox

Strain Name：C57BL/6Smoc-Pdcd1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-210063
Publications：1piece

These mice carry loxP sites flanking exon 2-4 of Pdcd1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pdcd1 gene.

Mice

Arg1-Flox

Strain Name：C57BL/6Smoc-Arg1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200062

These mice carry loxP sites flanking exon 5-8 of Arg1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Arg1 gene.

Mice

Eef2kmt-Flox

Strain Name：C57BL/6Smoc-Eef2kmtem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-234542

These strains carry loxP sites flanking exon 3-6 of Eef2kmt gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Eef2kmt gene.

Mice

Chi3l1-Flox

Strain Name：C57BL/6Smoc-Chil1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-241991

These strains carry loxP sites flanking exon 3-5 of Chil1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Chil1 gene.

Mice

Mir29a/Mir29b1-KO

Strain Name：C57BL/6Smoc-Mir29aem1 Mir29b-1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-00081

a 0.6kb region in length including Mir29a and Mir29b-1 pre-microRNAs was removed in this strain.

Mice

Cyp1a1/Cyp1a2-KO

Strain Name：C57BL/6Smoc-Cyp1a1em1Cyp1a2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-18018

Cyp1a1/1a2 was removed in this strain.

Mice

Cyp2c cluster-KO

Strain Name：C57BL/6Smoc-Cyp2c clusterem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-18019

the Cyp2c cluster was removed in this strain.

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