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Models

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Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence  |  Publications：1piece

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

Rag2/IL2rg/Flt3-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Rag2em1IL2rgem1Flt3em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-234080
Validation Data：Presence

In the background of Rag2/IL2rg-KO (BALB/c)(NM-KO-210231), the exon3 of Flt3 gene was knocked out to establish Rag2, IL2rg and Flt3 gene knockout mouse models.

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111
Validation Data：Presence

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429
Validation Data：Presence  |  Publications：2piece

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

Ythdf2-Flox

Strain Name：C57BL/6Smoc-Ythdf2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-190011

These mice carry loxP sites flanking exon3 of Ythdf2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ythdf2 gene.

Mice

Ythdf1-Flox

Strain Name：C57BL/6Smoc-Ythdf1tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190010

These mice carry loxP sites flanking exon3 of Ythdf1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ythdf1 gene.

Mice

Ythdf3-Flox

Strain Name：C57BL/6Smoc-Ythdf3em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-190012

These mice carry loxP sites flanking exon3 of Ythdf3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ythdf3 gene.

Mice

Apc-Flox

Strain Name：C57BL/6Smoc-Apctm2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200013

These mice carry loxP sites flanking exon 15 of Apc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Apc gene.

Mice

Dicer1-Flox

Strain Name：C57BL/6Smoc-Dicer1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200158

These mice carry loxP sites flanking exon 23 of Dicer1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dicer1 gene.

Mice

Ninj1-Flox

Strain Name：C57BL/6Smoc-Ninj1em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200039

These mice carry loxP sites flanking exon 2 of Ninj1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ninj1 gene.

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