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Models

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Mice

Rag2/IL2rg/Flt3-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Rag2em1IL2rgem1Flt3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234080

In the background of Rag2/IL2rg-KO (BALB/c)(NM-KO-210231), the exon3 of Flt3 gene was knocked out to establish Rag2, IL2rg and Flt3 gene knockout mouse models.

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001

Prkdc and Il2rg genes were both knocked-out in NOD mice.  Lacking mature T, B and NK cells Low immune rejection against human cells and tissues Good tumorigenicity so that a small number of cells can form tumors. Significant improvement in the survival of transplanted human cells and tissues Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models Suitable as the carrier mice for the transplantation of heterologous cells and tissues

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

Ythdf2-Flox

Strain Name：C57BL/6Smoc-Ythdf2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-190011

These mice carry loxP sites flanking exon3 of Ythdf2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ythdf2 gene.

Mice

Ythdf3-Flox

Strain Name：C57BL/6Smoc-Ythdf3em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-190012

These mice carry loxP sites flanking exon3 of Ythdf3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ythdf3 gene.

Mice

Ythdf1-Flox

Strain Name：C57BL/6Smoc-Ythdf1tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190010

These mice carry loxP sites flanking exon3 of Ythdf1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ythdf1 gene.

Mice

Wtap-Flox

Strain Name：C57BL/6Smoc-Wtapem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-190009

These mice carry loxP sites flanking exon3 of Wtap gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Wtap gene.

Mice

Apc-Flox

Strain Name：C57BL/6Smoc-Apctm2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200013

These mice carry loxP sites flanking exon 15 of Apc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Apc gene.

Mice

Dicer1-Flox

Strain Name：C57BL/6Smoc-Dicer1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200158

These mice carry loxP sites flanking exon 23 of Dicer1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dicer1 gene.

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