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Models

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Mice

Isl1-Cre

Strain Name：C57BL/6Smoc-Isl1em1(iCre-WPRE-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200126
Validation Data：Presence

A iCre-WPRE-pA expression cassette was knocked into the Isl1 gene start codon site.

Mice

hCXCR3

Strain Name：C57BL/6Smoc-Cxcr3tm1(hCXCR3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200219
Validation Data：Presence

The endogenous mouse Cxcr3 gene was completely or partially replaced by human CXCR3 gene via ESC targeting.

Mice

Myf6-CreERT2

Strain Name：C57BL/6Smoc-Myf6em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200125
Validation Data：Presence  |  Publications：1piece

A CreERT2-pA expression cassette was knocked into the Myf6 gene start codon site. Myf6 (myogenic factor 6) is a DNA-binding protein involved in muscle development. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Myf6.

Mice

hIL18BP

Strain Name：C57BL/6Smoc-Il18bptm1(hIL18BP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210039
Validation Data：Presence

The endogenous mice Il18bp gene was replaced by human IL18BP gene.

Mice

Xcr1-IRES-Cre

Strain Name：C57BL/6Smoc-Xcr1em1(IRES-iCre)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200237
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Xcr1 gene stop codon site.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105
Validation Data：Presence

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

Cd68-IRES-CreERT2

Strain Name：C57BL/6Smoc-Cd68em1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200162

A IRES-CreERT2 expression cassette was knocked into the Cd68 gene stop codon site.

Mice

S100a4-2A-CreERT2

Strain Name：C57BL/6Smoc-S100a4em1(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200024
Validation Data：Presence

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the S100a4 gene stop codon site.

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sortm1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

Mice

Ptf1a-CreERT2

Strain Name：C57BL/6Smoc-Ptf1aem1(CreERT2-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200118
Validation Data：Presence

A CreERT2-WPRE-pA expression cassette was knocked into the Ptf1a gene start codon site.

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