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Models

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Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6ratm1(hIL6R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025
Validation Data：Presence

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

H2/H2-K1-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1h2em2H2-K1em2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-NSG-006

Exon 2 of H2;H2-K1 gene was deleted to generate H2;H2-K1 knockout mice.

Mice

hIL17F

Strain Name：C57BL/6Smoc-Il17ftm2(hIL17F)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190007
Validation Data：Presence

The endogenous mouse Il17 gene was replaced by human IL17F gene.

Mice

hIL4RA

Strain Name：C57BL/6Smoc-Il4ratm1(hIL4R)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190008
Validation Data：Presence

The endogenous mouse Il4ra gene was replaced by human IL4R gene.

Mice

Cd200-KO

Strain Name：C57BL/6Smoc-Cd200em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190029

This Cd200 knockout mouse model was generated by knocking out the exon 2 region of the Cd200 .

Mice

Il33-KO(2)

Strain Name：C57BL/6Smoc-Il33em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190436
Validation Data：Presence  |  Publications：1piece

Il33-KO(2) mice(Stock No.NM-KO-190436) carry a knockout allele derived from the targeted deletion of exon 3-7. While Il33-KO mice(Stock No.NM-KO-00099) have been pulled from shelves for some reasons and Il33-KO(3) mice(Stock No.NM-KO-210206) carrying the exon 2 deletion.

Mice

R26-hCD46-IRES-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-hCD46-IRES-tdTomato-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190087
Validation Data：Presence

These mice harbor a SA-human CD46-IRES-tdTomato-polyA cassette in the Rosa26 locus generated by homologous recombination.

Mice

Snca-KO

Strain Name：C57BL/6Smoc-Sncaem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190380

This Snca knockout mouse model was generated by knocking out the exon4 region of the Snca.

Mice

hCXCR3

Strain Name：C57BL/6Smoc-Cxcr3tm1(hCXCR3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200219
Validation Data：Presence

The endogenous mouse Cxcr3 gene was completely or partially replaced by human CXCR3 gene via ESC targeting.

Mice

hIl5

Strain Name：C57BL/6Smoc-Il5tm3(hIL5)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190001
Validation Data：Presence

This IL5 humanized mouse model was established by replacing the mouse Il5 gene coding exons and introns with the human TLR9 corresponding sequence by homologous recombination.

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