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Models

About 233 results
Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001

Prkdc and Il2rg genes were both knocked-out in NOD mice.  Lacking mature T, B and NK cells Low immune rejection against human cells and tissues Good tumorigenicity so that a small number of cells can form tumors. Significant improvement in the survival of transplanted human cells and tissues Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models Suitable as the carrier mice for the transplantation of heterologous cells and tissues

Mice

hB7H4

Strain Name：C57BL/6Smoc-Vtcn1em1(hVTCN1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190004

This VTCN1 humanized mouse model was established by replacing the mouse Vtcn1 gene with the human VTCN1. While hB7H4(2)(Stock No.NM-HU-190075) mice function similarly to hB7H4 mice,for more detailed information please contact our technical advisor.

Mice

hTLR9

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-18016

This TLR9 humanized mouse model was established by replacing the mouse Tlr9 gene exon2 with the human TLR9 corresponding sequence by homologous recombination.

Mice

hAPOE2

Strain Name：C57BL/6Smoc-Apoetm4(hAPOE2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190013

This APOE2 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE2 corresponding sequence by homologous recombination.

Mice

hIl5

Strain Name：C57BL/6Smoc-Il5tm3(hIL5)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190001

This IL5 humanized mouse model was established by replacing the mouse Il5 gene coding exons and introns with the human TLR9 corresponding sequence by homologous recombination.

Mice

hAPOE4

Strain Name：C57BL/6Smoc-Apoetm2(hAPOE4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190002

This APOE4 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE4 corresponding sequence by homologous recombination.

Mice

hAPOE3

Strain Name：C57BL/6Smoc-Apoetm3(hAPOE3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190003

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.

Mice

hIL6

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18017

This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting.

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

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