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Models

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Mice

hSIGLEC15(BALB/c)

Strain Name：BALB/cAnSmoc-Siglec15tm2(hSIGLEC15) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200001
Validation Data：Presence

The endogenous mouse Siglec15 gene was replaced by human SIGLEC15 gene .

Mice

hMASP2

Strain Name：C57BL/6Smoc-Masp2tm1(hMASP2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000076
Validation Data：Presence

The endogenous mouse Masp2 gene was replaced by human MASP2 gene.

Mice

hFCGR2A

Strain Name：C57BL/6Smoc-Fcgr2btm3(hFCGR2A)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000071
Validation Data：Presence

The endogenous mouse Fcgr2b gene was replaced by human FCGR2A gene.

Mice

hCD3E/hSDC1

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Sdc1tm1(hSDC1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220021

hCD3E(NM-HU-00114) was crossed with hSDC1(NM-HU-2000026) to generate hCD3E/hSDC1 mice.

Mice

hIGHG1

Strain Name：C57BL/6Smoc-Ighg1tm1(hIGHG1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225091
Validation Data：Presence

The endogenous mouse Ighg1 gene was replaced by human IGHG1 gene.

Mice

hIFNGR2

Strain Name：C57BL/6Smoc-Ifngr2tm(hIFNGR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-215010
Validation Data：Presence

The endogenous mouse Ifngr2 gene was replaced by human IFNGR2 gene.

Mice

hPD-L1/hVISTA

Strain Name：C57BL/6Smoc-Visrtm1(hVSIR)Cd274tm1(hCD274)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000094

hPD-L1(NM-HU-00062) was crossed with hVISTA(NM-HU-00118) to generate hPD-L1/hVISTA.

Mice

hFAS

Strain Name：C57BL/6Smoc-Fastm1(hTNFRSF6)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-210007
Validation Data：Presence

The endogenous mice Fas gene was replaced by human FAS gene.

Mice

hICOS/hICOSL

Strain Name：C57BL/6Smoc-Icosltm1(hICOSLG) Icostm1(hICOS)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18018
Validation Data：Presence

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCD3E/hPD-L1

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd274tm1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210449
Validation Data：Presence

hCD3E(NM-HU-00114) was crossed with hPD-L1(NM-HU-00062) to generate hCD3E/hPD-L1 mice

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