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Models

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Mice

hVEGFA(2)

Strain Name：C57BL/6Smoc-Vegfatm1(hVEGFA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204984
Validation Data：Presence

The endogenous mice Vegfa gene was replaced by human VEGFA gene. While hVEGFA(Stock No.NM-HU-2000028) mice function similarly to hVEGFA(2) mice,for more detailed information please contact our technical advisor.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence  |  Publications：1piece

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

hCCR8/hCTLA-4

Strain Name：C57BL/6Smoc-Ccr8tm1(hCCR8)Ctla4tm1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210435

hCCR8(NM-HU-190053) was crossed with hCTLA4(NM-HU-00014) to generate hCCR8/hCTLA4 mice.

Mice

hFCRN(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Fcgrttm2(FCGRT)Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-020
Validation Data：Presence

The background of this strain is NMG, and its endogenous Fcgrt gene is replaced with human FCGRT.

Mice

hTLR9/hOX40

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Tnfrsf4tm3(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024

This TLR9 and OX40 double knockin strain is established by crossing TLR9-HU and OX40-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCSF1/hCSF1R(BALB/c)

Strain Name：BALB/cAnSmoc-Csf1tm2(CSF1)Csf1rtm3(hCSF1R)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220016
Validation Data：Presence

The endogenous mouse Csf1 and Csf1r genes was replaced respectively by human CSF1 and CSF1R genes.

Mice

hSEMA4D

Strain Name：C57BL/6Smoc-Sema4dtm1(hSEMA4D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00117
Validation Data：Presence

The endogenous mouse Sema4d gene was replaced by human SEMA4D gene.

Mice

hIL2/hIL2RA/hIL2RB/hIL2RG

Strain Name：C57BL/6Smoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)Il2rgtm1(IL2RG)Il2rbtm1(hIL2RB)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210415
Validation Data：Presence

hIL2/hIL2RA(NM-HU-200275) was crossed with hIL2RA/hIL2RB/hIL2RG(NM-HU-210414) to generate hIL2/hIL2RA/hIL2RB/hIL2RG mice.

Mice

hAPOE2

Strain Name：C57BL/6Smoc-Apoetm4(hAPOE2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190013
Validation Data：Presence

This APOE2 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE2 corresponding sequence by homologous recombination.

Mice

hCCR8(2)/hCTLA-4

Strain Name：C57BL/6Smoc-Ccr8tm3(hCCR8)Ctla4tm1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220074
Validation Data：Presence

hCTLA4 (NM-HU-00014) mice were crossed with hCCR8(2) (NM-HU-2000054) mice to generate hCCR8(2)/hCTLA4 mice．

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